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    Rpe ribulose-5-phosphate-3-epimerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501157, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpeprovided by RGD
    Official Full Name
    ribulose-5-phosphate-3-epimeraseprovided by RGD
    Primary source
    RGD:1564890
    See related
    EnsemblRapid:ENSRNOG00000038085 AllianceGenome:RGD:1564890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables D-ribulose-phosphate 3-epimerase activity and monosaccharide binding activity. Involved in pentose-phosphate shunt, non-oxidative branch. Predicted to be active in cytosol. Orthologous to several human genes including RPE (ribulose-5-phosphate-3-epimerase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 189.4), Kidney (RPKM 160.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpe in Genome Data Viewer
    Location:
    9q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (75640867..75661009)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (68191027..68211295)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (73687684..73713643)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 2 Neighboring gene unc-80 homolog, NALCN channel complex subunit Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC134480586 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene acyl-CoA dehydrogenase, long chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE. Liang W, et al. FASEB J, 2011 Feb. PMID 20923965, Free PMC Article
    2. Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE). Spencer N, et al. Ann Hum Genet, 1980 May. PMID 7396409
    3. The interdependence of glycolytic and pentose cycle intermediates in ad libitum fed rats. Casazza JP, et al. J Biol Chem, 1986 Jan 15. PMID 3079759
    4. A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis. Veech RL. Proc Natl Acad Sci U S A, 2003 May 13. PMID 12721358, Free PMC Article
    5. The pentose phosphate pathway in the endoplasmic reticulum. Bublitz C, et al. J Biol Chem, 1988 Sep 15. PMID 2843500

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124653

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-ribulose-phosphate 3-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-ribulose-phosphate 3-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-ribulose-phosphate 3-epimerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monosaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose-phosphate shunt IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose-phosphate shunt, non-oxidative branch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribulose-phosphate 3-epimerase
    NP_001029075.1
    NP_001386051.1
    NP_001386052.1
    NP_001386053.1
    NP_001386054.1
    NP_001386056.1
    XP_006245167.1
    XP_006245169.1
    XP_008765509.1
    XP_008765510.1
    XP_008765511.1
    XP_038940025.1
    XP_063123688.1
    XP_063123689.1
    XP_063123690.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033903.2 → NP_001029075.1  ribulose-phosphate 3-epimerase isoform 4

      See identical proteins and their annotated locations for NP_001029075.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      Q3MIF0
      Conserved Domains (1) summary
      cd00429
      Location:6 → 185
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    2. NM_001399122.1 → NP_001386051.1  ribulose-phosphate 3-epimerase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GEB4
      Related
      ENSRNOP00000086710.1, ENSRNOT00000116351.2
      Conserved Domains (1) summary
      cd00429
      Location:6 → 245
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    3. NM_001399123.1 → NP_001386052.1  ribulose-phosphate 3-epimerase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      Conserved Domains (1) summary
      cd00429
      Location:6 → 233
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    4. NM_001399124.1 → NP_001386053.1  ribulose-phosphate 3-epimerase isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6KFD1
      Related
      ENSRNOP00000069730.3, ENSRNOT00000079495.3
      Conserved Domains (1) summary
      cd00429
      Location:6 → 214
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    5. NM_001399125.1 → NP_001386054.1  ribulose-phosphate 3-epimerase isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      Conserved Domains (1) summary
      cd00429
      Location:1 → 151
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    6. NM_001399127.1 → NP_001386056.1  ribulose-phosphate 3-epimerase isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6KFD3
      Conserved Domains (1) summary
      cd00429
      Location:1 → 146
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      75640867..75661009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767288.4 → XP_008765510.1  ribulose-phosphate 3-epimerase isoform X3

      Conserved Domains (1) summary
      cd00429
      Location:6 → 221
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    2. XM_008767287.4 → XP_008765509.1  ribulose-phosphate 3-epimerase isoform X1

      Conserved Domains (1) summary
      cd00429
      Location:6 → 250
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    3. XM_006245105.5 → XP_006245167.1  ribulose-phosphate 3-epimerase isoform X2

      Conserved Domains (1) summary
      cd00429
      Location:6 → 238
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    4. XM_063267618.1 → XP_063123688.1  ribulose-phosphate 3-epimerase isoform X5

    5. XM_063267619.1 → XP_063123689.1  ribulose-phosphate 3-epimerase isoform X6

      Related
      ENSRNOP00000017197.6, ENSRNOT00000017197.9

    6. XM_006245107.5 → XP_006245169.1  ribulose-phosphate 3-epimerase isoform X4

      UniProtKB/TrEMBL
      A0A0G2JW38
      Conserved Domains (1) summary
      cd00429
      Location:6 → 219
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    7. XM_008767289.3 → XP_008765511.1  ribulose-phosphate 3-epimerase isoform X7

      Conserved Domains (1) summary
      cd00429
      Location:12 → 166
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...

    8. XM_063267620.1 → XP_063123690.1  ribulose-phosphate 3-epimerase isoform X8

    9. XM_039084097.2 → XP_038940025.1  ribulose-phosphate 3-epimerase isoform X7

      Conserved Domains (1) summary
      cd00429
      Location:12 → 166
      RPE; Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose ...
    Nucleotide Protein Strain
    Heading Accession and Version

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