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    POF1 nicotinamide-nucleotide adenylyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850310, updated on 9-Dec-2024

    Summary

    Official Symbol
    POF1
    Official Full Name
    nicotinamide-nucleotide adenylyltransferase
    Primary source
    SGD:S000000552
    Locus tag
    YCL047C
    See related
    AllianceGenome:SGD:S000000552; FungiDB:YCL047C; VEuPathDB:YCL047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP hydrolysis activity and nicotinamide-nucleotide adenylyltransferase activity. Involved in several processes, including NAD biosynthesis via nicotinamide riboside salvage pathway; invasive growth in response to glucose limitation; and pseudohyphal growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See POF1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (43661..44437, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sps22p Neighboring gene Emc1p Neighboring gene Mgr1p

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    nicotinamide-nucleotide adenylyltransferase
    NP_009883.1
    • Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinamide riboside (NR) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      43661..44437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178692.1 → NP_009883.1  TPA: nicotinamide-nucleotide adenylyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQX0, P25576
      UniProtKB/TrEMBL
      A6ZTE6, B3LU38, B5VER5, C7GT01, C8Z443, N1PAN9
      Conserved Domains (1) summary
      cd02165
      Location:31 → 254
      NMNAT; Nicotinamide/nicotinate mononucleotide adenylyltransferase
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