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    PML1 Pml1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850703, updated on 9-Dec-2024

    Summary

    Official Symbol
    PML1
    Official Full Name
    Pml1p
    Primary source
    SGD:S000004006
    Locus tag
    YLR016C
    See related
    AllianceGenome:SGD:S000004006; FungiDB:YLR016C; VEuPathDB:YLR016C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable mRNA binding activity. Involved in mRNA export from nucleus; mRNA splicing, via spliceosome; and maintenance of RNA location. Located in cytoplasm and nucleus. Part of RES complex. Orthologous to human SNIP1 (Smad nuclear interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See PML1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (176802..177416, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ppr1p Neighboring gene Bre2p Neighboring gene S-methyl-5-thioadenosine phosphorylase Neighboring gene Pom34p

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding  
    enables molecular_function  
    Process Evidence Code Pubs
    involved_in RNA splicing  
    involved_in mRNA export from nucleus PubMed 
    involved_in mRNA processing  
    involved_in mRNA splicing, via spliceosome  
    involved_in mRNA splicing, via spliceosome PubMed 
    involved_in maintenance of RNA location  
    involved_in maintenance of RNA location PubMed 
    Component Evidence Code Pubs
    part_of RES complex PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    Pml1p
    NP_013116.1
    • Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      176802..177416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181903.1 → NP_013116.1  TPA: Pml1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY18, Q06901, Q07930
      UniProtKB/TrEMBL
      A7A0S1, B3LSY9, B5VMV6, C7GXG2, C8ZCY8, G2WIL0
      Conserved Domains (1) summary
      cd00060
      Location:85 → 192
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
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