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    ECM16 ATP-dependent RNA helicase ECM16 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855158, updated on 4-Jan-2025

    Summary

    Official Symbol
    ECM16
    Official Full Name
    ATP-dependent RNA helicase ECM16
    Primary source
    SGD:S000004735
    Locus tag
    YMR128W
    See related
    AllianceGenome:SGD:S000004735; FungiDB:YMR128W; VEuPathDB:YMR128W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DHR1
    Summary
    Enables RNA helicase activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of small-subunit processome. Used to study microcephaly. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Orthologous to human DHX37 (DEAH-box helicase 37). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See ECM16 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (523696..527499)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Dlt1p Neighboring gene histone acetyltransferase Neighboring gene Pom152p Neighboring gene Dpi35p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables ATP-dependent activity, acting on RNA  
    enables DNA clamp loader activity  
    enables RNA binding  
    enables RNA binding  
    enables RNA helicase activity PubMed 
    enables RNA helicase activity  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables helicase activity  
    enables helicase activity  
    enables hydrolase activity  
    enables nucleic acid binding  
    Component Evidence Code Pubs
    part_of 90S preribosome PubMed 
    located_in mitochondrion PubMed 
    located_in nucleolus PubMed 
    is_active_in nucleolus  
    located_in nucleolus PubMed 
    located_in nucleolus  
    located_in nucleus  
    part_of ribonucleoprotein complex  
    part_of small-subunit processome PubMed 

    General protein information

    Preferred Names
    ATP-dependent RNA helicase ECM16
    NP_013847.1
    • Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; functions with methyltransferase Bud23p; predominantly nucleolar in distribution; required for 18S rRNA synthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      523696..527499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182629.1 → NP_013847.1  TPA: ATP-dependent RNA helicase ECM16 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013847.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZV1, Q04217
      UniProtKB/TrEMBL
      B3LM19, C8ZEY3
      Conserved Domains (1) summary
      COG1643
      Location:360 → 1267
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
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