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    ACC Acetyl-CoA carboxylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35761, updated on 9-Dec-2024

    Summary

    Official Symbol
    ACCprovided by FlyBase
    Official Full Name
    Acetyl-CoA carboxylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033246
    Locus tag
    Dmel_CG11198
    See related
    AllianceGenome:FB:FBgn0033246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A1Z784_DROME; acc; Acc; ACoT; CG11198; CG8723; dACC; DmACC; Dmel\CG11198; FBgn0043811
    Summary
    Predicted to enable acetyl-CoA carboxylase activity and biotin carboxylase activity. Involved in cellular response to sucrose stimulus and triglyceride biosynthetic process. Located in cytoplasm. Is expressed in several structures, including adult head; adult heart; embryonic/larval fat body; embryonic/larval gut; and embryonic/larval oenocyte. Used to study chromosome 17q12 deletion syndrome. Orthologous to several human genes including ACACB (acetyl-CoA carboxylase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See ACC in Genome Data Viewer
    Location:
    44A1-44A2; 2-58 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7974115..7991862, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3861620..3879367, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene spenito Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 4 Neighboring gene Nucleoporin at 44A Neighboring gene long non-coding RNA:CR44272 Neighboring gene Dicarboxylate carrier 3

    Genomic regions, transcripts, and products

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables acetyl-CoA carboxylase activity  
    enables acetyl-CoA carboxylase activity  
    enables acetyl-CoA carboxylase activity  
    enables biotin carboxylase activity  
    enables metal ion binding  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    Acetyl-CoA carboxylase
    Names
    ACC-PA
    ACC-PB
    ACC-PC
    ACC-PE
    ACC-PF
    ACC-PG
    CG11198-PA
    CG11198-PB
    CG11198-PC
    CG11198-PE
    CG11198-PF
    CG11198-PG
    aceto-acetyl-CoA-thiolase
    acetyl CoA carboxylase
    acetyl coenzyme A carboxylase
    acetyl-CoA carboxylase
    acetyl-CoA-carboxylase
    acetyl-coenzyme A carboxylase
    acyl-coA carboxylase
    NP_001097226.1
    NP_001097227.2
    NP_001286177.1
    NP_001286178.1
    NP_610342.1
    NP_724636.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7974115..7991862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299249.1 → NP_001286178.1  Acetyl-CoA carboxylase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286178.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JV23
      Conserved Domains (7) summary
      cd06850
      Location:732 → 793
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:101 → 598
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00289
      Location:101 → 220
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam01039
      Location:1641 → 2185
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:485 → 592
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:797 → 1541
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:225 → 448
      ATP-grasp_4; ATP-grasp domain
    2. NM_001299248.1 → NP_001286177.1  Acetyl-CoA carboxylase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JV23
      Conserved Domains (7) summary
      cd06850
      Location:732 → 793
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:101 → 598
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00289
      Location:101 → 220
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam01039
      Location:1641 → 2185
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:485 → 592
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:797 → 1541
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:225 → 448
      ATP-grasp_4; ATP-grasp domain
    3. NM_165581.3 → NP_724636.1  Acetyl-CoA carboxylase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724636.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JV23
      Related
      FBpp0087948
      Conserved Domains (7) summary
      cd06850
      Location:732 → 793
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:101 → 598
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00289
      Location:101 → 220
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam01039
      Location:1641 → 2185
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:485 → 592
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:797 → 1541
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:225 → 448
      ATP-grasp_4; ATP-grasp domain
    4. NM_136498.3 → NP_610342.1  Acetyl-CoA carboxylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610342.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z784
      Related
      FBpp0087947
      Conserved Domains (7) summary
      cd06850
      Location:891 → 952
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:260 → 757
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00289
      Location:260 → 379
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam01039
      Location:1800 → 2344
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:644 → 751
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:956 → 1700
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:384 → 607
      ATP-grasp_4; ATP-grasp domain
    5. NM_001103756.3 → NP_001097226.1  Acetyl-CoA carboxylase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097226.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JV23
      Conserved Domains (7) summary
      cd06850
      Location:732 → 793
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:101 → 598
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00289
      Location:101 → 220
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam01039
      Location:1641 → 2185
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:485 → 592
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:797 → 1541
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:225 → 448
      ATP-grasp_4; ATP-grasp domain
    6. NM_001103757.3 → NP_001097227.2  Acetyl-CoA carboxylase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097227.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY67
      Conserved Domains (7) summary
      cd06850
      Location:757 → 818
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:126 → 623
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00289
      Location:126 → 245
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam01039
      Location:1666 → 2210
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:510 → 617
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:822 → 1566
      ACC_central; Acetyl-CoA carboxylase, central region
      cl17255
      Location:250 → 473
      ATP-grasp_4; ATP-grasp domain
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