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    Hr4 Hormone receptor 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31162, updated on 17-Dec-2024

    Summary

    Official Symbol
    Hr4provided by FlyBase
    Official Full Name
    Hormone receptor 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0264562
    Locus tag
    Dmel_CG43934
    See related
    AllianceGenome:FB:FBgn0264562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null
    Old locus tag
    Dmel_CG16902; Dmel_CG3600; Dmel_CG42527
    Summary
    Enables nuclear receptor activity. Involved in cellular response to hypoxia; regulation of developmental growth; and regulation of pupariation. Located in cytoplasm and nucleus. Is expressed in border follicle cell; centripetal follicle cell; embryonic/larval fat body; prothoracic gland; and ring gland. Orthologous to human NR6A1 (nuclear receptor subfamily 6 group A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Hr4 in Genome Data Viewer
    Location:
    2B16-2C1; 1-0.5 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1941940..2007956)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1835973..1901989)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene long non-coding RNA:CR45478 Neighboring gene mir-2496 stem loop Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class K

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity  
    enables estrogen response element binding  
    enables nuclear receptor activity  
    enables nuclear receptor activity PubMed 
    enables nuclear receptor activity PubMed 
    enables sequence-specific DNA binding  
    enables zinc ion binding  
    Component Evidence Code Pubs
    located_in chromatin  
    located_in cytoplasm PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    hormone receptor 4
    Names
    CG43934-PC
    CG43934-PD
    CG43934-PE
    CG43934-PF
    CG43934-PG
    CG43934-PH
    CG43934-PI
    CG43934-PJ
    CG43934-PK
    Hr4-PC
    Hr4-PD
    Hr4-PE
    Hr4-PF
    Hr4-PG
    Hr4-PH
    Hr4-PI
    Hr4-PJ
    Hr4-PK

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1941940..2007956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272234.1 → NP_001259163.1  hormone receptor 4, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA3
      Conserved Domains (2) summary
      cd06953
      Location:1580 → 1839
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:1237 → 1326
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers
    2. NM_001272233.2 → NP_001259162.1  hormone receptor 4, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA3
      Conserved Domains (2) summary
      cd06953
      Location:1580 → 1839
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:1237 → 1326
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers
    3. NM_001272230.1 → NP_001259159.1  hormone receptor 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259159.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGH1
      Conserved Domains (2) summary
      cd06953
      Location:1266 → 1525
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:923 → 1012
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers
    4. NM_001272227.1 → NP_001259156.1  hormone receptor 4, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259156.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDJ1
      Conserved Domains (2) summary
      cd06953
      Location:1723 → 1982
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:1380 → 1469
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers
    5. NM_001272231.1 → NP_001259160.1  hormone receptor 4, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259160.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PIR5
      Conserved Domains (2) summary
      cd06953
      Location:1256 → 1515
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:913 → 1002
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers
    6. NM_001272232.1 → NP_001259161.1  hormone receptor 4, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDJ5
      Conserved Domains (2) summary
      cd06953
      Location:1256 → 1515
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:913 → 1002
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers
    7. NM_001038734.2 → NP_001033823.1  hormone receptor 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033823.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96836, Q56AW0, Q9W539
      Conserved Domains (2) summary
      cd06953
      Location:1256 → 1514
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:913 → 1002
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers
    8. NM_001272229.1 → NP_001259158.1  hormone receptor 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259158.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGQ8
      Conserved Domains (2) summary
      cd06953
      Location:1580 → 1838
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:1237 → 1326
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers
    9. NM_001272228.1 → NP_001259157.1  hormone receptor 4, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259157.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA1
      Conserved Domains (2) summary
      cd06953
      Location:1349 → 1607
      NR_LBD_DHR4_like; The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4
      cd07168
      Location:1006 → 1095
      NR_DBD_DHR4_like; DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers
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