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    br broad [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    brprovided by FlyBase
    Official Full Name
    broadprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283451
    Locus tag
    Dmel_CG11491
    See related
    AllianceGenome:FB:FBgn0283451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2B5; 2Bc; A18; Br; BR; br-c; br-C; Br-c; Br-C; BR-c; BR-C; BR-C Z1; Br-C Z2; Br-C-Z3; br-Z1; BR-Z1; br-Z2; BR-Z2; br-Z3; BR-Z3; br-Z4; Br-Z4; BR-Z4; BrC; BRC; BrC-Z1; BRC-Z1; BRC-Z2; BRC-Z3; BRC-Z4; Broad; BrZ3; BR_C; CG11491; CG11509; CG11511; CG11514; de12; Dmel\CG11491; ecs; EG:123F11.1; EG:17A9.1; EG:25D2.1; l(1)2Ba; l(1)2Bab; l(1)2Bad; l(1)2Bb; l(1)2Bc; l(1)2Bd; l(1)d norm-12; l(1)d.norm.1; l(1)dn1; l(1)ESHS5; l(1)G0018; l(1)G0042; l(1)G0284; l(1)G0284a; l(1)G0318; l(1)G0401; l(1)n34; l(1)npr-1; l(1)npr1; l(1)pp-1; l(1)pp-2; l(1)pp1; l(1)PP1; l(1)pp2; l(1)ts132; l(1)ts144; l(1)ts358; l(1)ts376; npr; npr-1; npr1; nprl; nrp; nrp1; o.c.c.; PP1; PP2; rbp; rdp; rds; uq; Z1; Z2; Z3; Z4
    Old locus tag
    Dmel_CG11509
    Summary
    Enables DNA-binding transcription repressor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including compound eye morphogenesis; dorsal appendage formation; and regulation of gene expression. Located in neuronal cell body; nucleus; and polytene chromosome. Is expressed in several structures, including anterior-posterior subdivision of organism; brain; follicle cell; gland; and thoracic neuromere. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    2B3-2B5; 1-0.2 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1575132..1664869)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1469165..1558902)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene insomniac Neighboring gene uncharacterized protein Neighboring gene Mucin related 2B Neighboring gene small non-coding RNA 400 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene deep orange Neighboring gene halfway

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Imaginal disc development in a non-pupariating lethal mutant inDrosophila melanogaster. Fristrom DK, et al. Wilehm Roux Arch Dev Biol, 1981 Jan. PMID 28305365
    2. Differential expression of Broad-Complex transcription factors may forecast tissue-specific developmental fates during Drosophila metamorphosis. Emery IF, et al. Development, 1994 Nov. PMID 7720567
    3. Enhancer-trap targeting at the Broad-Complex locus of Drosophila melanogaster. Gonzy-Tréboul G, et al. Genes Dev, 1995 May 1. PMID 7744254
    4. Cytogenetic analysis of the 2B3-4--2B11 region of the X chromosome of Drosophila melanogaster. III. Puffing disturbance in salivary gland chromosomes of homozygotes for mutation l(1)pp1t10. Zhimulev IF, et al. Chromosoma, 1982. PMID 6813059
    5. [Cloning the BR-C gene in Drosophila virilis]. Doronkin SG, et al. Genetika, 1998 Apr. PMID 9612700

    See all (576) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development.
      Title: The Broad Transcription Factor Links Hormonal Signaling, Gene Expression, and Cellular Morphogenesis Events During Drosophila Imaginal Disc Development.
    2. let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State.
      Title: let-7-Complex MicroRNAs Regulate Broad-Z3, Which Together with Chinmo Maintains Adult Lineage Neurons in an Immature State.
    3. Broad as an important cell-intrinsic transcription factor that promotes the neuroepithelial-cell-to-neuroblast transition.
      Title: Broad Promotes Neuroepithelial Stem Cell Differentiation in the Drosophila Optic Lobe.
    4. Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors Chinmo and Broad.
      Title: Developmental regulation of regenerative potential in Drosophila by ecdysone through a bistable loop of ZBTB transcription factors.
    5. Polytene chromosome stains showed that Cg co-localizes with EcR, the major regulator of BR-C, at the BR-C locus and that EcR binding to chromatin was sensitive to changes in Cg levels
      Title: Combgap Promotes Ovarian Niche Development and Chromatin Association of EcR-Binding Regions in BR-C.
    6. The CSN suppresses Sens through repression of the ecdysone signaling target gene broad (br) that encodes the BR-Z1 transcription factor to activate sens expression
      Title: The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence.
    7. Early gene Broad complex(BR-C) could be regulating the immune pathways by activating Relish and physically interacting with it to activate antimicrobial peptides expression.
      Title: Early gene Broad complex plays a key role in regulating the immune response triggered by ecdysone in the Malpighian tubules of Drosophila melanogaster.
    8. broad (br), encoding a small group of zinc-finger transcription factors resulting from alternative splicing, is a transcriptional target of Notch nuclear effector Suppressor of Hairless (Su(H)).
      Title: Regulation of broad by the Notch pathway affects timing of follicle cell development.
    9. Understanding Broad expression is impossible without simultaneously considering two enhancers, a dynamic gradient, and a network with extracellular and intracellular components.
      Title: Dynamic model for the coordination of two enhancers of broad by EGFR signaling.
    10. Broad (Br)-mediated hormone signaling regulates AMP specification
      Title: Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to ecdysone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to ecdysone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye photoreceptor fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal appendage formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eclosion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gravitaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in progression of morphogenetic furrow involved in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of development, heterochronic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ecdysone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to symbiont IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salivary gland histolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    broad
    Names
    Br-C
    CG11491-PA
    CG11491-PB
    CG11491-PC
    CG11491-PE
    CG11491-PG
    CG11491-PH
    CG11491-PI
    CG11491-PJ
    CG11491-PL
    CG11491-PM
    CG11491-PN
    CG11491-PO
    CG11491-PP
    CG11491-PQ
    CG11491-PR
    CG11491-PS
    br-PA
    br-PB
    br-PC
    br-PE
    br-PG
    br-PH
    br-PI
    br-PJ
    br-PL
    br-PM
    br-PN
    br-PO
    br-PP
    br-PQ
    br-PR
    br-PS
    broad complex
    broad-complex
    ecdysone-sensitivity
    lethal(1)2Bab
    lethal(1)2Bc
    lethal(1)2Bd
    lethal(1)discs normal
    lethal(1)non-pupariating-1
    non-pupariating
    non-pupariating-1
    overlapping-complementation-complex
    reduced bristles on palps
    reduced palps
    unequal wings

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1575132..1664869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201598.1 → NP_001188527.1  broad, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188527.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46065, O46066, Q01293, Q01295, Q01296, Q9W571, Q9W574
      UniProtKB/TrEMBL
      M9MSM6
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00020
      Location:635 → 662
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    2. NM_001258533.1 → NP_001245462.1  broad, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245462.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46065, O46066, Q01293, Q01295, Q01296, Q9W571, Q9W574
      UniProtKB/TrEMBL
      D8FT05
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00020
      Location:574 → 601
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    3. NM_001144672.3 → NP_001138144.1  broad, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138144.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46064, Q24206, Q9W575
      UniProtKB/TrEMBL
      A4V3U8, Q9W572
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:712 → 729
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    4. NM_166897.2 → NP_726753.1  broad, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726753.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46064, Q24206, Q9W575
      UniProtKB/TrEMBL
      A4V3U8, Q9W572
      Related
      FBpp0070251
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:712 → 729
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    5. NM_001169167.2 → NP_001162638.2  broad, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162638.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJB2
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:712 → 729
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    6. NM_001201596.3 → NP_001188525.1  broad, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188525.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRX4
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:441 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    7. NM_166894.4 → NP_726750.1  broad, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6G6CYY5
      Related
      FBpp0070255
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:589 → 610
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    8. NM_166893.3 → NP_726749.2  broad, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726749.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRX4
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:441 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    9. NM_001382013.1 → NP_001368968.1  broad, isoform R [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EEH5
      Conserved Domains (2) summary
      sd00017
      Location:441 → 462
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18315
      Location:31 → 114
      BTB_POZ_BAB-like; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins

    10. NM_166896.3 → NP_726752.1  broad, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726752.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46064, Q24206, Q9W575
      UniProtKB/TrEMBL
      A4V3U8, Q9W572
      Related
      FBpp0070253
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:712 → 729
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    11. NM_001272205.1 → NP_001259134.1  broad, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259134.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46064, Q24206, Q9W575
      UniProtKB/TrEMBL
      A4V3U8, Q9W572
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:712 → 729
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    12. NM_080020.4 → NP_524759.2  broad, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524759.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46065, O46066, Q01293, Q01295, Q01296, Q9W571, Q9W574
      UniProtKB/TrEMBL
      M9MSM6
      Related
      FBpp0070252
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00020
      Location:635 → 662
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    13. NM_166898.2 → NP_726754.1  broad, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726754.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46065, O46066, Q01293, Q01295, Q01296, Q9W571, Q9W574
      UniProtKB/TrEMBL
      D8FT05
      Related
      FBpp0070256
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00020
      Location:574 → 601
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    14. NM_166895.2 → NP_726751.2  broad, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726751.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46064, Q24206, Q9W575
      UniProtKB/TrEMBL
      A4V3U8, Q9W572
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:712 → 729
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain

    15. NM_001414056.1 → NP_001401048.1  broad, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6G6CYY5

    16. NM_001201597.1 → NP_001188526.1  broad, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188526.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46065, O46066, Q01293, Q01295, Q01296, Q9W571, Q9W574
      UniProtKB/TrEMBL
      M9MSM6
      Conserved Domains (3) summary
      smart00225
      Location:33 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00020
      Location:635 → 662
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 118
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6H2EEH5 A0A6H2EEH5
    D8FT05 D8FT05
    E1JJB2 E1JJB2
    M9MSM6 M9MSM6
    Q01295.2 Q01295
    Q24206.2 Q24206
    Q7K2S6 Q7K2S6
    Q8IRX4 Q8IRX4
    Q9W572 Q9W572

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