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    CG8028 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8028provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031010
    Locus tag
    Dmel_CG8028
    See related
    AllianceGenome:FB:FBgn0031010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8028; MCT
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Involved in renal tubular secretion and response to toxic substance. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to several human genes including SLC16A11 (solute carrier family 16 member 11); SLC16A12 (solute carrier family 16 member 12); and SLC16A3 (solute carrier family 16 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8028 in Genome Data Viewer
    Location:
    18B8-18B9; 1-62 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19277176..19280349, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19171209..19174382, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Vav guanine nucleotide exchange factor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 763 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult Drosophila melanogaster. Chahine S, et al. J Insect Physiol, 2009 Oct. PMID 19545574
    2. Effects of acute or chronic exposure to dietary organic anions on secretion of methotrexate and salicylate by Malpighian tubules of Drosophila melanogaster larvae. Chahine S, et al. Arch Insect Biochem Physiol, 2010 Mar. PMID 20077573
    3. A single pair of leucokinin neurons are modulated by feeding state and regulate sleep-metabolism interactions. Yurgel ME, et al. PLoS Biol, 2019 Feb. PMID 30759083, Free PMC Article
    4. Glial Glycolysis Is Essential for Neuronal Survival in Drosophila. Volkenhoff A, et al. Cell Metab, 2015 Sep 1. PMID 26235423
    5. Updates on ion and water transport by the Malpighian tubule. Dow JAT, et al. Curr Opin Insect Sci, 2021 Oct. PMID 33705976, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in renal tubular secretion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8028-PC
    CG8028-PD
    monocarboxylate transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19277176..19280349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103561.2 → NP_001097031.2  uncharacterized protein Dmel_CG8028, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097031.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUR0
      Conserved Domains (1) summary
      cd06174
      Location:40 → 215
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    2. NM_133147.2 → NP_573375.2  uncharacterized protein Dmel_CG8028, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573375.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWJ2
      Conserved Domains (2) summary
      cd06174
      Location:1 → 138
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:1 → 160
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUR0 A8JUR0
    Q6AWN8 Q6AWN8
    Q9VWJ2 Q9VWJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials