TrpA1 Transient receptor potential cation channel A1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TrpA1provided by FlyBase
Official Full Name: Transient receptor potential cation channel A1provided by FlyBase
Primary source: FLYBASE:FBgn0035934
Locus tag: Dmel_CG5751
See related: AllianceGenome:FB:FBgn0035934
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Anktm1; ANKTM1; CG5751; CG5761; CT18073; dANKTM1; Dmel\CG5751; dmTRPA1; DmTRPA1; dTrpA; dTRPA; dtrpA1; dTrpA1; dTRPA1; Trp; Trp1A; TrpA; TRPA; trpa1; trpA1; Trpa1; TrPA1; TRPA1
Summary: Enables calcium channel activity; ligand-gated monoatomic ion channel activity; and temperature-gated cation channel activity. Involved in several processes, including detection of stimulus involved in sensory perception; monoatomic cation transport; and negative phototaxis. Part of cation channel complex. Is active in plasma membrane. Is expressed in several structures, including adult pacemaker neurons; ganglia; segment of antenna; sensillum; and sensory neurons. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66E3-66E3; 3-27 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8894404..8905200, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8887504..8897890, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation in Drosophila.
Title: TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation in Drosophila.
Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1.
Title: Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1.
bserved allyl isothiocyanate-evoked responses in both painless and dTRPA1 expressing neurons
Title: Behavioral Aversion to AITC Requires Both Painless and dTRPA1 in Drosophila.
We show that signalling through the TrpA1 thermo-sensor is required for PMW, and that TrpA1 specifically impacts siesta onset, but not night sleep onset, in response to elevated temperatures. We identify two critical TrpA1-expressing circuits and show that both contact DN1p clock neurons, the output of which is also required for PMW.
Title: Regulation of sleep plasticity by a thermo-sensitive circuit in Drosophila.
This review discusses the various roles that TRPA1 plays in temperature related behaviors with a main focus on the underlying neuronal circuits. [review]
Title: The Drosophila TRPA1 Channel and Neuronal Circuits Controlling Rhythmic Behaviours and Sleep in Response to Environmental Temperature.
Characterization of TRPA1 and RyR demonstrates that Ca(2+) signaling is required for oxidative stress-induced activation of the Ras/MAPK pathway, which in turns drives intestinal stem cell proliferation.
Title: Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca(2+) signaling in the Drosophila midgut.
study shows that activity/rest rhythms are modulated in a temperature-dependent manner via signals from dTRPA1(SH)-GAL4 driven neurons. Taken together, these results emphasize the differential influence of thermoreceptors on rhythmic behavior in fruit flies in coordination with light inputs.
Title: dTRPA1 in Non-circadian Neurons Modulates Temperature-dependent Rhythmic Activity in Drosophila melanogaster.
Rh5 and Rh6 were required in trpA1-expressing neurons in the brain, ventral nerve cord, and body wall. Because Rh1 contributes to thermal selection in the comfortable range during the early to mid-third-instar stage, fine thermal discrimination depends on multiple rhodopsins.
Title: A Switch in Thermal Preference in Drosophila Larvae Depends on Multiple Rhodopsins.
These findings demonstrate that Drosophila detects bacterial endotoxins via a gustatory pathway through TRPA1 activation as conserved molecular mechanism.
Title: Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila.
Collectively, TRPA1 A isoform rapidly responds to natural sunlight intensities through its nucleophile sensitivity as a receptor of photochemically generated radicals, leading to an acute light-induced behavioral shift in Drosophila.
Title: Nucleophile sensitivity of Drosophila TRPA1 underlies light-induced feeding deterrence.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
NOT enables bitter taste receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables temperature-gated cation channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to pulsatile fluid shear stress	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of hot stimulus involved in thermoception	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of hot stimulus involved in thermoception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus involved in thermoception	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of temperature stimulus involved in thermoception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative phototaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in temperature compensation of the circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cation channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IC Inferred by Curator more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transient receptor potential cation channel A1

Names: CG5751-PG; CG5751-PH; CG5751-PI; CG5751-PJ; CG5751-PK; TrPA1; TrpA1-PG; TrpA1-PH; TrpA1-PI; TrpA1-PJ; TrpA1-PK; dTRPA1; transient receptor potential A 1; transient receptor potential A1; transient receptor potential cation channel; transient receptor potential cation channel A1 ortholog; transient-receptor-potential A1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8894404..8905200 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274673.2 → NP_001261602.1 transient receptor potential cation channel A1, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261602.1

Status: REVIEWED

UniProtKB/TrEMBL

G9L8C4, M9PBX8

Conserved Domains (4) summary

cd00204
Location:473 → 599

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:821 → 1037

Ion_trans; Ion transport protein

pfam12796
Location:483 → 572

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:478 → 509

ANK; ANK repeat [structural motif]
NM_001274672.2 → NP_001261601.1 transient receptor potential cation channel A1, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261601.1

Status: REVIEWED

UniProtKB/TrEMBL

G9L8C4, H0USS9

Conserved Domains (4) summary

cd00204
Location:473 → 599

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:857 → 1073

Ion_trans; Ion transport protein

pfam12796
Location:483 → 572

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:478 → 509

ANK; ANK repeat [structural motif]
NM_001274671.2 → NP_001261600.1 transient receptor potential cation channel A1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261600.1

Status: REVIEWED

UniProtKB/TrEMBL

G8IQ59, G9L8C4

Conserved Domains (4) summary

cd00204
Location:473 → 599

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:858 → 1074

Ion_trans; Ion transport protein

pfam12796
Location:483 → 572

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:478 → 509

ANK; ANK repeat [structural motif]
NM_001104084.5 → NP_001097554.4 transient receptor potential cation channel A1, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097554.4

Status: REVIEWED

UniProtKB/TrEMBL

G9L8C4, H0UST1

Conserved Domains (4) summary

cd00204
Location:438 → 564

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:822 → 1038

Ion_trans; Ion transport protein

pfam12796
Location:448 → 537

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:443 → 474

ANK; ANK repeat [structural motif]
NM_140006.6 → NP_648263.5 transient receptor potential cation channel A1, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648263.5

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JNP0, Q7Z020, Q9VSQ9

UniProtKB/TrEMBL

G9L8C4

Conserved Domains (4) summary

cd00204
Location:438 → 564

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:823 → 1039

Ion_trans; Ion transport protein

pfam12796
Location:448 → 537

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:443 → 474

ANK; ANK repeat [structural motif]