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    para paralytic [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32619, updated on 9-Dec-2024

    Summary

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    Official Symbol
    paraprovided by FlyBase
    Official Full Name
    paralyticprovided by FlyBase
    Primary source
    FLYBASE:FBgn0285944
    Locus tag
    Dmel_CG9907
    See related
    AllianceGenome:FB:FBgn0285944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bas; bss; CG9907; Dmel\CG9907; DmNav; DmNav1; DmNa[[v]]; DmNa[[V]]; DmNa[[v]]1; l(1)14Da; l(1)ESHS48; lincRNA.S9469; Nav1; Ocd; olfD; par; Para; para13-5; sbl; sbl-1; Scn1alpha; Shu; Shudderer; VSSC
    Summary
    Enables voltage-gated sodium channel activity. Involved in several processes, including male courtship behavior, veined wing generated song production; mechanosensory behavior; and sodium ion transmembrane transport. Located in plasma membrane. Is expressed in adult brain; adult brain cell body rind; adult ventral nerve cord; and eye. Used to study Dravet syndrome; epilepsy; generalized epilepsy with febrile seizures plus; and generalized epilepsy with febrile seizures plus 2. Human ortholog(s) of this gene implicated in several diseases, including congenital myopathy (multiple); epilepsy (multiple); heart conduction disease (multiple); intrinsic cardiomyopathy (multiple); and neuropathy (multiple). Orthologous to several human genes including SCN3A (sodium voltage-gated channel alpha subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See para in Genome Data Viewer
    Location:
    14C8-14E1; 1-54 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16455027..16533096, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16349060..16427129, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 4H1 Neighboring gene Calnexin 14D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin. Martin RL, et al. Insect Biochem Mol Biol, 2000 Nov. PMID 10989292
    2. Reversing insecticide resistance with allelic-drive in Drosophila melanogaster. Kaduskar B, et al. Nat Commun, 2022 Jan 12. PMID 35022402, Free PMC Article
    3. Generation and Characterization of the Drosophila melanogaster paralytic Gene Knock-Out as a Model for Dravet Syndrome. Tapia A, et al. Life (Basel), 2021 Nov 18. PMID 34833136, Free PMC Article
    4. Sodium current density correlates with expression of specific alternatively spliced sodium channel mRNAs in single neurons. O'Dowd DK, et al. J Neurosci, 1995 May. PMID 7751961, Free PMC Article
    5. Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current. Schutte RJ, et al. J Neurophysiol, 2014 Aug 15. PMID 24805083, Free PMC Article

    See all (443) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Voltage-Gated Sodium Channel in Drosophila, Para, Localizes to Dendrites As Well As Axons in Mechanosensitive Chordotonal Neurons.
      Title: The Voltage-Gated Sodium Channel in Drosophila, Para, Localizes to Dendrites As Well As Axons in Mechanosensitive Chordotonal Neurons.
    2. Loss of paralytic (para), the sole gene that encodes Drosophila voltage-gated sodium channels, reduces neuroblast progeny cell number
      Title: Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors.
    3. Study identified Shu, a Drosophila mutation causing severe behavioral defects, as a novel hypermorphic allele of the Nav channel gene para. Results suggest that the Shu Nav channels cause an increase in sodium currents, and that this defect is compensated by reduced para function, leading to a more balanced neuronal output.
      Title: Lithium-Responsive Seizure-Like Hyperexcitability Is Caused by a Mutation in the Drosophila Voltage-Gated Sodium Channel Gene paralytic.
    4. analysis revealed that 2 variant-specific amino acid changes, I260T in the S4-S5 linker of domain I (ILS4-S5) and A1731V in the voltage sensor S4 of domain IV (IVS4), contribute to the persistent sodium current (INaP)
      Title: Sequence variations at I260 and A1731 contribute to persistent currents in Drosophila sodium channels.
    5. Trp404 and His405 as a putative point of Av3 interaction with DmNav1.
      Title: The specificity of Av3 sea anemone toxin for arthropods is determined at linker DI/SS2-S6 in the pore module of target sodium channels.
    6. The para(bss1) has not responded to seizure suppressor mutations identified in screens based on the Drosophila mutants eas protein and sda protein.
      Title: Drosophila as a model for intractable epilepsy: gilgamesh suppresses seizures in para(bss1) heterozygote flies.
    7. results indicate that increased synaptic activity influences the decision to splice in exon L, which, in turn, may promote seizure.
      Title: Activity-dependent alternative splicing increases persistent sodium current and promotes seizure.
    8. 3-dimensional structure modeling of ANEPII and site-4 of the insect sodium channel were carried out by homology modeling, and these models were used as the starting point for nanosecond-duration molecular dynamics simulations.
      Title: Study of the binding residues between ANEPII and insect sodium channel receptor.
    9. Drosomycin interacts with the voltage-gated sodium channel, DmNa(v)1.
      Title: Drosomycin, an innate immunity peptide of Drosophila melanogaster, interacts with the fly voltage-gated sodium channel.
    10. The structure of the scorpion alpha-toxin LqhalphaIT binding site in the para sodium channel of Drosophila melanogaster was characterized using NMR Spectroscopy.
      Title: NMR analysis of interaction of LqhalphaIT scorpion toxin with a peptide corresponding to the D4/S3-S4 loop of insect para voltage-gated sodium channel.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c16498220-16492701 mobile_element_type = transposon:mdg3{}144
    • Loc: c16522733-16522684 mobile_element_type = transposon:Rt1b{}4197
    • Loc: c16522920-16522849 mobile_element_type = transposon:Rt1c{}4198

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated sodium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables voltage-gated sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated sodium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in male courtship behavior, veined wing generated song production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuronal action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated sodium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    paralytic
    Names
    CG9907-PA
    CG9907-PAA
    CG9907-PAB
    CG9907-PAC
    CG9907-PAD
    CG9907-PAE
    CG9907-PAF
    CG9907-PAG
    CG9907-PAH
    CG9907-PAI
    CG9907-PAJ
    CG9907-PAK
    CG9907-PAL
    CG9907-PAM
    CG9907-PAN
    CG9907-PAO
    CG9907-PAP
    CG9907-PAQ
    CG9907-PAR
    CG9907-PAS
    CG9907-PAT
    CG9907-PAU
    CG9907-PAV
    CG9907-PAW
    CG9907-PAX
    CG9907-PAY
    CG9907-PAZ
    CG9907-PB
    CG9907-PBA
    CG9907-PBB
    CG9907-PBC
    CG9907-PBD
    CG9907-PBE
    CG9907-PBF
    CG9907-PBG
    CG9907-PBH
    CG9907-PC
    CG9907-PD
    CG9907-PE
    CG9907-PF
    CG9907-PG
    CG9907-PH
    CG9907-PI
    CG9907-PJ
    CG9907-PK
    CG9907-PL
    CG9907-PM
    CG9907-PN
    CG9907-PO
    CG9907-PP
    CG9907-PQ
    CG9907-PR
    CG9907-PS
    CG9907-PT
    CG9907-PU
    CG9907-PV
    CG9907-PW
    CG9907-PX
    CG9907-PY
    CG9907-PZ
    Out cold
    Out-cold
    bang senseless
    bang sensitive
    bang-senseless
    bangsenseless
    para-PA
    para-PAA
    para-PAB
    para-PAC
    para-PAD
    para-PAE
    para-PAF
    para-PAG
    para-PAH
    para-PAI
    para-PAJ
    para-PAK
    para-PAL
    para-PAM
    para-PAN
    para-PAO
    para-PAP
    para-PAQ
    para-PAR
    para-PAS
    para-PAT
    para-PAU
    para-PAV
    para-PAW
    para-PAX
    para-PAY
    para-PAZ
    para-PB
    para-PBA
    para-PBB
    para-PBC
    para-PBD
    para-PBE
    para-PBF
    para-PBG
    para-PBH
    para-PC
    para-PD
    para-PE
    para-PF
    para-PG
    para-PH
    para-PI
    para-PJ
    para-PK
    para-PL
    para-PM
    para-PN
    para-PO
    para-PP
    para-PQ
    para-PR
    para-PS
    para-PT
    para-PU
    para-PV
    para-PW
    para-PX
    para-PY
    para-PZ
    paralyzed
    shudderer
    smell-blind
    smellblind
    voltage gated sodium ion channel
    voltage-sensitive sodium channel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16455027..16533096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298403.1 → NP_001285332.1  paralytic, isoform BG [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285332.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O15994, P35500, P92137, Q0KHR8, Q0KHR9, Q24082, Q24083, Q24084, Q24528, Q24529, Q24530, Q24531, Q24532, Q9VXF7
      UniProtKB/TrEMBL
      X2JKQ0
      Conserved Domains (5) summary
      cd13433
      Location:1561 → 1613
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1318 → 1571
      Ion_trans; Ion transport protein
      pfam06512
      Location:1054 → 1296
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1880 → 1930
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    2. NM_001201703.3 → NP_001188632.1  paralytic, isoform AK [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS66
      Conserved Domains (5) summary
      cd13433
      Location:1527 → 1579
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1284 → 1537
      Ion_trans; Ion transport protein
      pfam06512
      Location:1043 → 1262
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1846 → 1896
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    3. NM_001201695.2 → NP_001188624.1  paralytic, isoform AC [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSP5
      Conserved Domains (5) summary
      cd13433
      Location:1514 → 1566
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1271 → 1524
      Ion_trans; Ion transport protein
      pfam06512
      Location:1030 → 1249
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 624
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1833 → 1883
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    4. NM_001298404.1 → NP_001285333.1  paralytic, isoform BH [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285333.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JFE8
      Conserved Domains (5) summary
      cd13433
      Location:1485 → 1537
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1560 → 1795
      Ion_trans; Ion transport protein
      pfam06512
      Location:1042 → 1261
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:503 → 636
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1804 → 1854
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    5. NM_001201710.1 → NP_001188639.1  paralytic, isoform AR [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188639.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSP8

    6. NM_001201714.1 → NP_001188643.1  paralytic, isoform AV [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS99
      Conserved Domains (3) summary
      pfam00520
      Location:752 → 945
      Ion_trans; Ion transport protein
      pfam06512
      Location:971 → 1015
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:461 → 573
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

    7. NM_001201713.1 → NP_001188642.1  paralytic, isoform AU [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188642.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSD9
      Conserved Domains (3) summary
      pfam00520
      Location:760 → 953
      Ion_trans; Ion transport protein
      pfam06512
      Location:979 → 1023
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:461 → 573
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

    8. NM_001201712.1 → NP_001188641.1  paralytic, isoform AT [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSE9
      Conserved Domains (5) summary
      cd13433
      Location:1486 → 1538
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1243 → 1496
      Ion_trans; Ion transport protein
      pfam06512
      Location:979 → 1221
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:461 → 573
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1805 → 1855
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    9. NM_001201711.1 → NP_001188640.1  paralytic, isoform AS [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS96
      Conserved Domains (5) summary
      cd13433
      Location:1497 → 1549
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1254 → 1507
      Ion_trans; Ion transport protein
      pfam06512
      Location:1000 → 1232
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:461 → 594
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1816 → 1866
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    10. NM_001201721.1 → NP_001188650.1  paralytic, isoform BC [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188650.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSA4
      Conserved Domains (2) summary
      pfam00520
      Location:154 → 425
      Ion_trans; Ion transport protein
      pfam11933
      Location:504 → 592
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

    11. NM_001201715.1 → NP_001188644.1  paralytic, isoform AW [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188644.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSP9
      Conserved Domains (5) summary
      cd13433
      Location:1492 → 1544
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1249 → 1502
      Ion_trans; Ion transport protein
      pfam06512
      Location:998 → 1227
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 592
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1811 → 1861
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    12. NM_001201705.1 → NP_001188634.1  paralytic, isoform AM [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188634.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSP7
      Conserved Domains (5) summary
      cd13433
      Location:1513 → 1565
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1270 → 1523
      Ion_trans; Ion transport protein
      pfam06512
      Location:1019 → 1248
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 613
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1832 → 1882
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    13. NM_001201701.1 → NP_001188630.1  paralytic, isoform AI [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188630.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS88
      Conserved Domains (5) summary
      cd13433
      Location:1516 → 1568
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1273 → 1526
      Ion_trans; Ion transport protein
      pfam06512
      Location:1022 → 1251
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 616
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1835 → 1885
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    14. NM_001201696.1 → NP_001188625.1  paralytic, isoform AD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188625.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS84
      Conserved Domains (5) summary
      cd13433
      Location:1516 → 1568
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1273 → 1526
      Ion_trans; Ion transport protein
      pfam06512
      Location:1022 → 1251
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 616
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1835 → 1885
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    15. NM_001201704.1 → NP_001188633.1  paralytic, isoform AL [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188633.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS91
      Conserved Domains (5) summary
      cd13433
      Location:1541 → 1593
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1298 → 1551
      Ion_trans; Ion transport protein
      pfam06512
      Location:1022 → 1276
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 616
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1860 → 1910
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    16. NM_001201718.1 → NP_001188647.1  paralytic, isoform AZ [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188647.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSE1
      Conserved Domains (5) summary
      cd13433
      Location:1541 → 1593
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1298 → 1551
      Ion_trans; Ion transport protein
      pfam06512
      Location:1022 → 1276
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 616
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1860 → 1910
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    17. NM_001201699.1 → NP_001188628.1  paralytic, isoform AG [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188628.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS87
      Conserved Domains (5) summary
      cd13433
      Location:1519 → 1571
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1276 → 1529
      Ion_trans; Ion transport protein
      pfam06512
      Location:1022 → 1254
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 616
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1838 → 1888
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    18. NM_001201723.1 → NP_001188652.1  paralytic, isoform BE [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSE3
      Conserved Domains (2) summary
      pfam00520
      Location:154 → 425
      Ion_trans; Ion transport protein
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

    19. NM_001201716.1 → NP_001188645.1  paralytic, isoform AX [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188645.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSA0
      Conserved Domains (5) summary
      cd13433
      Location:1529 → 1581
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1286 → 1539
      Ion_trans; Ion transport protein
      pfam06512
      Location:1035 → 1264
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1848 → 1898
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    20. NM_001144733.2 → NP_001138205.1  paralytic, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138205.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0Z2
      Conserved Domains (5) summary
      cd13433
      Location:1544 → 1596
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1301 → 1554
      Ion_trans; Ion transport protein
      pfam06512
      Location:1035 → 1279
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1863 → 1913
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    21. NM_001201722.1 → NP_001188651.1  paralytic, isoform BD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188651.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSF2
      Conserved Domains (5) summary
      cd13433
      Location:1486 → 1538
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1561 → 1796
      Ion_trans; Ion transport protein
      pfam06512
      Location:1043 → 1262
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1805 → 1855
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    22. NM_001201674.1 → NP_001188603.1  paralytic, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188603.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS66
      Conserved Domains (5) summary
      cd13433
      Location:1527 → 1579
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1284 → 1537
      Ion_trans; Ion transport protein
      pfam06512
      Location:1043 → 1262
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1846 → 1896
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    23. NM_001201720.1 → NP_001188649.1  paralytic, isoform BB [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188649.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSQ0
      Conserved Domains (5) summary
      cd13433
      Location:1496 → 1548
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1571 → 1806
      Ion_trans; Ion transport protein
      pfam06512
      Location:1043 → 1272
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1815 → 1865
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    24. NM_001201700.1 → NP_001188629.1  paralytic, isoform AH [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188629.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSP6
      Conserved Domains (5) summary
      cd13433
      Location:1537 → 1589
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1294 → 1547
      Ion_trans; Ion transport protein
      pfam06512
      Location:1043 → 1272
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1856 → 1906
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    25. NM_001201702.1 → NP_001188631.1  paralytic, isoform AJ [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188631.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSE6
      Conserved Domains (5) summary
      cd13433
      Location:1562 → 1614
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1319 → 1572
      Ion_trans; Ion transport protein
      pfam06512
      Location:1043 → 1297
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1881 → 1931
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    26. NM_001201717.1 → NP_001188646.1  paralytic, isoform AY [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188646.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSF1
      Conserved Domains (5) summary
      cd13433
      Location:1562 → 1614
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1319 → 1572
      Ion_trans; Ion transport protein
      pfam06512
      Location:1043 → 1297
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1881 → 1931
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    27. NM_001201698.1 → NP_001188627.1  paralytic, isoform AF [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188627.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSD2
      Conserved Domains (5) summary
      cd13433
      Location:1540 → 1592
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1297 → 1550
      Ion_trans; Ion transport protein
      pfam06512
      Location:1043 → 1275
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1859 → 1909
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    28. NM_001201719.1 → NP_001188648.1  paralytic, isoform BA [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSA3
      Conserved Domains (5) summary
      cd13433
      Location:1562 → 1614
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1319 → 1572
      Ion_trans; Ion transport protein
      pfam06512
      Location:1043 → 1297
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:504 → 637
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1881 → 1931
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    29. NM_001201683.1 → NP_001188612.1  paralytic, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSC3
      Conserved Domains (5) summary
      cd13433
      Location:1506 → 1558
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1263 → 1516
      Ion_trans; Ion transport protein
      pfam06512
      Location:1022 → 1241
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 624
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1825 → 1875
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    30. NM_001201677.1 → NP_001188606.1  paralytic, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188606.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSD7
      Conserved Domains (5) summary
      cd13433
      Location:1506 → 1558
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1263 → 1516
      Ion_trans; Ion transport protein
      pfam06512
      Location:1022 → 1241
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 624
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1825 → 1875
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    31. NM_001201694.1 → NP_001188623.1  paralytic, isoform AB [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS83
      Conserved Domains (5) summary
      cd13433
      Location:1516 → 1568
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1273 → 1526
      Ion_trans; Ion transport protein
      pfam06512
      Location:1022 → 1251
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 624
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1835 → 1885
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    32. NM_001201692.1 → NP_001188621.1  paralytic, isoform Z [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSE2
      Conserved Domains (5) summary
      cd13433
      Location:1519 → 1571
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1276 → 1529
      Ion_trans; Ion transport protein
      pfam06512
      Location:1022 → 1254
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 624
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1838 → 1888
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    33. NM_001201693.1 → NP_001188622.1  paralytic, isoform AA [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSP5
      Conserved Domains (5) summary
      cd13433
      Location:1514 → 1566
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1271 → 1524
      Ion_trans; Ion transport protein
      pfam06512
      Location:1030 → 1249
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 624
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1833 → 1883
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    34. NM_001201675.1 → NP_001188604.1  paralytic, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188604.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSP1
      Conserved Domains (5) summary
      cd13433
      Location:1509 → 1561
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1266 → 1519
      Ion_trans; Ion transport protein
      pfam06512
      Location:1025 → 1244
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 627
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1828 → 1878
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    35. NM_001201709.1 → NP_001188638.1  paralytic, isoform AQ [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS95
      Conserved Domains (5) summary
      cd13433
      Location:1519 → 1571
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1276 → 1529
      Ion_trans; Ion transport protein
      pfam06512
      Location:1025 → 1254
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 627
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1838 → 1888
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    36. NM_001201681.1 → NP_001188610.1  paralytic, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS71
      Conserved Domains (5) summary
      cd13433
      Location:1522 → 1574
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1279 → 1532
      Ion_trans; Ion transport protein
      pfam06512
      Location:1025 → 1257
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 627
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1841 → 1891
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    37. NM_001201689.1 → NP_001188618.1  paralytic, isoform W [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS78
      Conserved Domains (5) summary
      cd13433
      Location:1532 → 1584
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1289 → 1542
      Ion_trans; Ion transport protein
      pfam06512
      Location:1025 → 1267
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 627
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1851 → 1901
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    38. NM_001201684.1 → NP_001188613.1  paralytic, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS73
      Conserved Domains (5) summary
      cd13433
      Location:1509 → 1561
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1266 → 1519
      Ion_trans; Ion transport protein
      pfam06512
      Location:1025 → 1244
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 627
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1828 → 1878
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    39. NM_001201673.1 → NP_001188602.1  paralytic, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188602.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSB4
      Conserved Domains (5) summary
      cd13433
      Location:1517 → 1569
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1274 → 1527
      Ion_trans; Ion transport protein
      pfam06512
      Location:1033 → 1252
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 627
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1836 → 1886
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    40. NM_001201688.1 → NP_001188617.1  paralytic, isoform V [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188617.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSC7
      Conserved Domains (5) summary
      cd13433
      Location:1527 → 1579
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1284 → 1537
      Ion_trans; Ion transport protein
      pfam06512
      Location:1033 → 1262
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 627
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1846 → 1896
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    41. NM_001201708.1 → NP_001188637.1  paralytic, isoform AP [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188637.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSD6
      Conserved Domains (5) summary
      cd13433
      Location:1527 → 1579
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1284 → 1537
      Ion_trans; Ion transport protein
      pfam06512
      Location:1033 → 1262
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 627
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1846 → 1896
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    42. NM_001201680.1 → NP_001188609.1  paralytic, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSP2
      Conserved Domains (5) summary
      cd13433
      Location:1530 → 1582
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1287 → 1540
      Ion_trans; Ion transport protein
      pfam06512
      Location:1033 → 1265
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 627
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1849 → 1899
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    43. NM_001201678.1 → NP_001188607.1  paralytic, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSB8
      Conserved Domains (5) summary
      cd13433
      Location:1517 → 1569
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1274 → 1527
      Ion_trans; Ion transport protein
      pfam06512
      Location:1033 → 1252
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 627
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1836 → 1886
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    44. NM_001201685.1 → NP_001188614.1  paralytic, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSP3
      Conserved Domains (5) summary
      cd13433
      Location:1530 → 1582
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1287 → 1540
      Ion_trans; Ion transport protein
      pfam06512
      Location:1033 → 1265
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 627
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1849 → 1899
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    45. NM_001201679.1 → NP_001188608.1  paralytic, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS69
      Conserved Domains (5) summary
      cd13433
      Location:1530 → 1582
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1287 → 1540
      Ion_trans; Ion transport protein
      pfam06512
      Location:1046 → 1265
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1849 → 1899
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    46. NM_001201686.1 → NP_001188615.1  paralytic, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188615.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS75
      Conserved Domains (5) summary
      cd13433
      Location:1540 → 1592
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1297 → 1550
      Ion_trans; Ion transport protein
      pfam06512
      Location:1046 → 1275
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1859 → 1909
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    47. NM_001201707.1 → NP_001188636.1  paralytic, isoform AO [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188636.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSE7
      Conserved Domains (5) summary
      cd13433
      Location:1543 → 1595
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1300 → 1553
      Ion_trans; Ion transport protein
      pfam06512
      Location:1046 → 1278
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1862 → 1912
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    48. NM_001201676.1 → NP_001188605.1  paralytic, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188605.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS65
      Conserved Domains (5) summary
      cd13433
      Location:1530 → 1582
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1287 → 1540
      Ion_trans; Ion transport protein
      pfam06512
      Location:1046 → 1265
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1849 → 1899
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    49. NM_001201690.1 → NP_001188619.1  paralytic, isoform X [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSP4
      Conserved Domains (5) summary
      cd13433
      Location:1555 → 1607
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1312 → 1565
      Ion_trans; Ion transport protein
      pfam06512
      Location:1046 → 1290
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1874 → 1924
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    50. NM_001201691.1 → NP_001188620.1  paralytic, isoform Y [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188620.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS79
      Conserved Domains (5) summary
      cd13433
      Location:1568 → 1620
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1325 → 1578
      Ion_trans; Ion transport protein
      pfam06512
      Location:1046 → 1303
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1887 → 1937
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    51. NM_001201671.1 → NP_001188600.1  paralytic, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS61
      Conserved Domains (5) summary
      cd13433
      Location:1538 → 1590
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1295 → 1548
      Ion_trans; Ion transport protein
      pfam06512
      Location:1054 → 1273
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1857 → 1907
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    52. NM_001201697.1 → NP_001188626.1  paralytic, isoform AE [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188626.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSE4
      Conserved Domains (5) summary
      cd13433
      Location:1538 → 1590
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1295 → 1548
      Ion_trans; Ion transport protein
      pfam06512
      Location:1054 → 1273
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1857 → 1907
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    53. NM_001201687.1 → NP_001188616.1  paralytic, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188616.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSE0
      Conserved Domains (5) summary
      cd13433
      Location:1548 → 1600
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1305 → 1558
      Ion_trans; Ion transport protein
      pfam06512
      Location:1054 → 1283
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1867 → 1917
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    54. NM_001201706.1 → NP_001188635.1  paralytic, isoform AN [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188635.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS92
      Conserved Domains (5) summary
      cd13433
      Location:1573 → 1625
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1330 → 1583
      Ion_trans; Ion transport protein
      pfam06512
      Location:1054 → 1308
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1892 → 1942
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    55. NM_001201682.1 → NP_001188611.1  paralytic, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSD8
      Conserved Domains (5) summary
      cd13433
      Location:1551 → 1603
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1308 → 1561
      Ion_trans; Ion transport protein
      pfam06512
      Location:1054 → 1286
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1870 → 1920
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    56. NM_078647.4 → NP_523371.2  paralytic, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523371.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O15994, P35500, P92137, Q0KHR8, Q0KHR9, Q24082, Q24083, Q24084, Q24528, Q24529, Q24530, Q24531, Q24532, Q9VXF7
      UniProtKB/TrEMBL
      X2JKQ0
      Related
      FBpp0074073
      Conserved Domains (5) summary
      cd13433
      Location:1561 → 1613
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1318 → 1571
      Ion_trans; Ion transport protein
      pfam06512
      Location:1054 → 1296
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1880 → 1930
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    57. NM_001272690.1 → NP_001259619.1  paralytic, isoform BF [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259619.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PJP5
      Conserved Domains (5) summary
      cd13433
      Location:1561 → 1613
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1318 → 1571
      Ion_trans; Ion transport protein
      pfam06512
      Location:1054 → 1296
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1880 → 1930
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    58. NM_001042815.2 → NP_001036280.1  paralytic, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036280.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35500
      Conserved Domains (5) summary
      cd13433
      Location:1561 → 1613
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1318 → 1571
      Ion_trans; Ion transport protein
      pfam06512
      Location:1054 → 1296
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1880 → 1930
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    59. NM_001201672.1 → NP_001188601.1  paralytic, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSD5
      Conserved Domains (5) summary
      cd13433
      Location:1538 → 1590
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1295 → 1548
      Ion_trans; Ion transport protein
      pfam06512
      Location:1054 → 1273
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1857 → 1907
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    60. NM_001042816.2 → NP_001036281.1  paralytic, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036281.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35500
      Conserved Domains (5) summary
      cd13433
      Location:1561 → 1613
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:1318 → 1571
      Ion_trans; Ion transport protein
      pfam06512
      Location:1054 → 1296
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:515 → 648
      Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel
      pfam16905
      Location:1880 → 1930
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0Z2 B7Z0Z2
    M9MS61 M9MS61
    M9MS65 M9MS65
    M9MS66 M9MS66
    M9MS69 M9MS69
    M9MS71 M9MS71
    M9MS73 M9MS73
    M9MS75 M9MS75
    M9MS78 M9MS78
    M9MS79 M9MS79
    M9MS83 M9MS83
    M9MS84 M9MS84
    M9MS87 M9MS87
    M9MS88 M9MS88
    M9MS91 M9MS91
    M9MS92 M9MS92
    M9MS95 M9MS95
    M9MS96 M9MS96
    M9MS99 M9MS99
    M9MSA0 M9MSA0
    M9MSA3 M9MSA3
    M9MSA4 M9MSA4
    M9MSB4 M9MSB4
    M9MSB8 M9MSB8
    M9MSC3 M9MSC3
    M9MSC7 M9MSC7
    M9MSD2 M9MSD2
    M9MSD5 M9MSD5
    M9MSD6 M9MSD6
    M9MSD7 M9MSD7
    M9MSD8 M9MSD8
    M9MSD9 M9MSD9
    M9MSE0 M9MSE0
    M9MSE1 M9MSE1
    M9MSE2 M9MSE2
    M9MSE3 M9MSE3
    M9MSE4 M9MSE4
    M9MSE6 M9MSE6
    M9MSE7 M9MSE7
    M9MSE9 M9MSE9
    M9MSF1 M9MSF1
    M9MSF2 M9MSF2
    M9MSP1 M9MSP1
    M9MSP2 M9MSP2
    M9MSP3 M9MSP3
    M9MSP4 M9MSP4
    M9MSP5 M9MSP5
    M9MSP6 M9MSP6
    M9MSP7 M9MSP7
    M9MSP8 M9MSP8
    M9MSP9 M9MSP9
    M9MSQ0 M9MSQ0
    M9PJP5 M9PJP5
    P35500.3 P35500
    X2JFE8 X2JFE8
    X2JKQ0 X2JKQ0

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