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    GRS2 putative glycine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856196, updated on 4-Jan-2025

    Summary

    Official Symbol
    GRS2
    Official Full Name
    putative glycine--tRNA ligase
    Primary source
    SGD:S000006285
    Locus tag
    YPR081C
    See related
    AllianceGenome:SGD:S000006285; FungiDB:YPR081C; VEuPathDB:YPR081C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glycine-tRNA ligase activity. Involved in glycyl-tRNA aminoacylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and autosomal dominant distal hereditary motor neuronopathy 5. Orthologous to human GARS1 (glycyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See GRS2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (702114..703970, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mrl1p Neighboring gene translation elongation factor EF-1 alpha Neighboring gene U4/U6-U5 snRNP complex subunit DIB1 Neighboring gene Mdm36p

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP:ATP adenylyltransferase activity  
    enables aminoacyl-tRNA ligase activity  
    enables catalytic activity, acting on a tRNA  
    enables glycine-tRNA ligase activity  
    enables glycine-tRNA ligase activity PubMed 
    enables glycine-tRNA ligase activity  
    enables glycine-tRNA ligase activity PubMed 
    enables transferase activity  
    Process Evidence Code Pubs
    involved_in glycyl-tRNA aminoacylation  
    involved_in glycyl-tRNA aminoacylation PubMed 
    involved_in mitochondrial glycyl-tRNA aminoacylation  
    involved_in tRNA aminoacylation for protein translation  
    involved_in translation  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in mitochondrion  

    General protein information

    Preferred Names
    putative glycine--tRNA ligase
    NP_015406.1
    • Glycine-tRNA synthetase, not expressed under normal growth conditions; expression is induced under heat, oxidative, pH, or ethanol stress conditions; more stable than the major glycine-tRNA synthetase Grs1p at 37 deg C; GRS2 has a paralog, GRS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      702114..703970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184178.1 → NP_015406.1  TPA: putative glycine--tRNA ligase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015406.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W483, Q06817
      UniProtKB/TrEMBL
      A6ZWW6, B3LK51, C7GPS4, C8ZJA6, N1NXM5
      Conserved Domains (1) summary
      TIGR00389
      Location:7 → 598
      glyS_dimeric; glycyl-tRNA synthetase, dimeric type
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