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    IDE insulin degrading enzyme [ Gallus gallus (chicken) ]

    Gene ID: 423814, updated on 3-Dec-2024

    Summary

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    Symbol
    IDEprovided by CGNC
    Full Name
    insulin degrading enzymeprovided by CGNC
    Primary source
    CGNC:5184
    See related
    Ensembl:ENSGALG00010021405
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See IDE in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (21544340..21606406)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (21435565..21497433)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121111227 Neighboring gene kinesin family member 11 Neighboring gene membrane associated ring-CH-type finger 5 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene uncharacterized LOC101750135

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Cloning and expression analysis of chicken circular transcript of insulin degrading enzyme gene]. Leng QY, et al. Yi Chuan, 2019 Dec 20. PMID 31857284
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    insulin-degrading enzyme
    XP_004942214.4
    XP_040531358.1
    XP_040531359.1
    XP_040531360.1
    XP_040531361.1
    XP_040531362.1
    XP_040531363.1
    XP_040559035.1
    XP_040559036.1
    XP_040559037.1
    XP_040559038.1
    XP_040559039.1
    XP_046776380.1
    XP_046776381.1
    XP_046798941.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      21544340..21606406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040703104.2 → XP_040559038.1  insulin-degrading enzyme isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZQD7, A0A8V0ZQF0
      Conserved Domains (1) summary
      COG1025
      Location:4 → 917
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    2. XM_040703105.2 → XP_040559039.1  insulin-degrading enzyme isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZQD7, A0A8V0ZQF0
      Related
      ENSGALP00010030963.1, ENSGALT00010051895.1
      Conserved Domains (1) summary
      COG1025
      Location:4 → 917
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    3. XM_040703102.2 → XP_040559036.1  insulin-degrading enzyme isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZQD7
      Conserved Domains (1) summary
      COG1025
      Location:47 → 960
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    4. XM_046942985.1 → XP_046798941.1  insulin-degrading enzyme isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZQD7, A0A8V0ZQF0

    5. XM_040703101.2 → XP_040559035.1  insulin-degrading enzyme isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZQD7
      Conserved Domains (1) summary
      COG1025
      Location:47 → 960
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    6. XM_004942157.5 → XP_004942214.4  insulin-degrading enzyme isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZI42, A0A8V0ZQD7
      Related
      ENSGALP00010030984.1, ENSGALT00010051917.1
      Conserved Domains (1) summary
      COG1025
      Location:47 → 960
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    7. XM_040703103.1 → XP_040559037.1  insulin-degrading enzyme isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZQD7, A0A8V0ZQF0
      Conserved Domains (1) summary
      COG1025
      Location:4 → 917
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      21435565..21497433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040675428.2 → XP_040531362.1  insulin-degrading enzyme isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZQD7, A0A8V0ZQF0
      Conserved Domains (1) summary
      COG1025
      Location:4 → 917
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    2. XM_046920424.1 → XP_046776380.1  insulin-degrading enzyme isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZQD7, A0A8V0ZQF0

    3. XM_040675429.2 → XP_040531363.1  insulin-degrading enzyme isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZQD7, A0A8V0ZQF0
      Conserved Domains (1) summary
      COG1025
      Location:4 → 917
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    4. XM_040675426.2 → XP_040531360.1  insulin-degrading enzyme isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZQD7
      Conserved Domains (1) summary
      COG1025
      Location:47 → 960
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    5. XM_046920425.1 → XP_046776381.1  insulin-degrading enzyme isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZQD7, A0A8V0ZQF0

    6. XM_040675425.2 → XP_040531359.1  insulin-degrading enzyme isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZQD7
      Conserved Domains (1) summary
      COG1025
      Location:47 → 960
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    7. XM_040675424.2 → XP_040531358.1  insulin-degrading enzyme isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZI42, A0A8V0ZQD7
      Conserved Domains (1) summary
      COG1025
      Location:47 → 960
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    8. XM_040675427.1 → XP_040531361.1  insulin-degrading enzyme isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZQD7, A0A8V0ZQF0
      Conserved Domains (1) summary
      COG1025
      Location:4 → 917
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version

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