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    DPL1 sphinganine-1-phosphate aldolase DPL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851888, updated on 9-Dec-2024

    Summary

    Official Symbol
    DPL1
    Official Full Name
    sphinganine-1-phosphate aldolase DPL1
    Primary source
    SGD:S000002702
    Locus tag
    YDR294C
    See related
    AllianceGenome:SGD:S000002702; FungiDB:YDR294C; VEuPathDB:YDR294C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BST1
    Summary
    Enables sphinganine-1-phosphate aldolase activity. Involved in calcium-mediated signaling; cellular response to starvation; and sphingolipid metabolic process. Located in cortical endoplasmic reticulum and perinuclear endoplasmic reticulum. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See DPL1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1050459..1052228, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Signal recognition particle receptor subunit alpha Neighboring gene mRNA-binding translational repressor SSD1 Neighboring gene Hda2p Neighboring gene mitochondrial 54S ribosomal protein MHR1

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carbon-carbon lyase activity  
    enables lyase activity  
    enables pyridoxal phosphate binding  
    enables sphinganine-1-phosphate aldolase activity  
    enables sphinganine-1-phosphate aldolase activity PubMed 
    enables sphinganine-1-phosphate aldolase activity  
    Component Evidence Code Pubs
    located_in cortical endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum PubMed 
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in membrane  
    located_in perinuclear endoplasmic reticulum PubMed 
    located_in peroxisome PubMed 

    General protein information

    Preferred Names
    sphinganine-1-phosphate aldolase DPL1
    NP_010580.1
    • Dihydrosphingosine phosphate lyase; regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate; localizes to the ER and to the peroxisome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1050459..1052228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180602.1 → NP_010580.1  TPA: sphinganine-1-phosphate aldolase DPL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010580.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSS3, Q05567
      UniProtKB/TrEMBL
      C7GQU4, C8Z5K6, N1P6T8
      Conserved Domains (1) summary
      COG0076
      Location:106 → 543
      GadA; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]
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