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    ATG3 Atg3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855741, updated on 9-Dec-2024

    Summary

    Official Symbol
    ATG3
    Official Full Name
    Atg3p
    Primary source
    SGD:S000005290
    Locus tag
    YNR007C
    See related
    AllianceGenome:SGD:S000005290; FungiDB:YNR007C; VEuPathDB:YNR007C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APG3; AUT1
    Summary
    Enables Atg8-family ligase activity. Involved in several processes, including C-terminal protein lipidation; cytoplasm to vacuole targeting by the Cvt pathway; and macroautophagy. Located in phagophore and phagophore assembly site. Orthologous to human ATG3 (autophagy related 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ATG3 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (639182..640114, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Swm2p Neighboring gene ESCRT-0 subunit protein VPS27 Neighboring gene phospholipid:diacylglycerol acyltransferase Neighboring gene Nrm1p

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_001146.8

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in C-terminal protein lipidation PubMed 
    involved_in C-terminal protein lipidation PubMed 
    involved_in autophagosome assembly  
    involved_in autophagosome assembly PubMed 
    involved_in autophagy  
    involved_in autophagy of mitochondrion  
    involved_in autophagy of mitochondrion PubMed 
    involved_in cytoplasm to vacuole targeting by the Cvt pathway PubMed 
    involved_in glycophagy  
    involved_in nucleophagy  
    involved_in nucleophagy PubMed 
    involved_in piecemeal microautophagy of the nucleus PubMed 
    involved_in protein transport  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol PubMed 
    is_active_in cytosol  
    located_in mitochondrion  
    located_in phagophore PubMed 
    located_in phagophore PubMed 
    is_active_in phagophore assembly site  
    located_in phagophore assembly site PubMed 

    General protein information

    Preferred Names
    Atg3p
    NP_014404.3
    • E2-like enzyme; involved in autophagy and cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p regulated by acetylation by NuA4 histone acetyltransferase Esa1p while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; Atg12p-Atg5p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      639182..640114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183184.3 → NP_014404.3  TPA: Atg3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014404.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZS81, D6W1I2, P40344
      UniProtKB/TrEMBL
      B3LPN3, B5VR38, C7GLP8, C8ZFN4, G2WL64, N1NY52
      Conserved Domains (2) summary
      pfam03986
      Location:2 → 141
      Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain
      pfam03987
      Location:32 → 305
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
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