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    Srrm1 serine/arginine repetitive matrix 1 [ Mus musculus (house mouse) ]

    Gene ID: 51796, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Srrm1provided by MGI
    Official Full Name
    serine/arginine repetitive matrix 1provided by MGI
    Primary source
    MGI:MGI:1858303
    See related
    Ensembl:ENSMUSG00000028809 AllianceGenome:MGI:1858303
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    POP101; Srm160
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA splicing, via spliceosome. Part of spliceosomal complex. Is expressed in central nervous system; genitourinary system; pancreas epithelium; and sensory organ. Orthologous to human SRRM1 (serine and arginine repetitive matrix 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 32.0), CNS E11.5 (RPKM 29.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srrm1 in Genome Data Viewer
    Location:
    4 D3; 4 67.34 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135047795..135080787, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135320484..135353277, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11711 Neighboring gene predicted gene, 30701 Neighboring gene STARR-positive B cell enhancer ABC_E10266 Neighboring gene predicted gene 12984 Neighboring gene STARR-positive B cell enhancer ABC_E6233 Neighboring gene noncompact myelin associated protein Neighboring gene regulator of calcineurin 3 Neighboring gene microRNA 700

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A coactivator of pre-mRNA splicing. Blencowe BJ, et al. Genes Dev, 1998 Apr 1. PMID 9531537, Free PMC Article
    2. UPF2 is a critical regulator of liver development, function and regeneration. Thoren LA, et al. PLoS One, 2010 Jul 19. PMID 20657840, Free PMC Article
    3. Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Sutherland HG, et al. Hum Mol Genet, 2001 Sep 1. PMID 11555636
    4. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
    5. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing, via transesterification reactions ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/arginine repetitive matrix protein 1
    Names
    Ser/Arg-related nuclear matrix protein
    plenty-of-prolines-101

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130477.2 → NP_001123949.1  serine/arginine repetitive matrix protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) lacks 5 amino acids in the N-terminus, compared to isoform 1.
      Source sequence(s)
      AL627078, AL627185
      Consensus CDS
      CCDS51329.1
      UniProtKB/TrEMBL
      A2A8V9, E9QKA4
      Related
      ENSMUSP00000081906.6, ENSMUST00000084846.12
      Conserved Domains (2) summary
      pfam00906
      Location:621 → 712
      Hepatitis_core; Hepatitis core antigen
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    2. NM_001369067.1 → NP_001355996.1  serine/arginine repetitive matrix protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627078, AL627185
      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:623 → 820
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    3. NM_001369068.1 → NP_001355997.1  serine/arginine repetitive matrix protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627078, AL627185
      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:622 → 819
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    4. NM_001369069.1 → NP_001355998.1  serine/arginine repetitive matrix protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL627078, AL627185
      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03247
      Location:611 → 806
      PHA03247; large tegument protein UL36; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    5. NM_001369070.1 → NP_001355999.1  serine/arginine repetitive matrix protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL627078, AL627185
      Consensus CDS
      CCDS89844.1
      UniProtKB/TrEMBL
      A2A8V8, E9QKA4
      Related
      ENSMUSP00000101487.2, ENSMUST00000105861.8
      Conserved Domains (2) summary
      PHA03247
      Location:389 → 805
      PHA03247; large tegument protein UL36; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    6. NM_001369071.1 → NP_001356000.1  serine/arginine repetitive matrix protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL627078, AL627185
      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03247
      Location:389 → 804
      PHA03247; large tegument protein UL36; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    7. NM_001369072.1 → NP_001356001.1  serine/arginine repetitive matrix protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL627078, AL627185
      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:594 → 791
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    8. NM_001369073.1 → NP_001356002.1  serine/arginine repetitive matrix protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL627078, AL627185
      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03247
      Location:389 → 775
      PHA03247; large tegument protein UL36; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    9. NM_001369074.1 → NP_001356003.1  serine/arginine repetitive matrix protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL627078, AL627185
      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:511 → 708
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    10. NM_016799.4 → NP_058079.2  serine/arginine repetitive matrix protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL627078, AL627185
      Consensus CDS
      CCDS38919.2
      UniProtKB/TrEMBL
      E9PUK6, E9QKA4
      Related
      ENSMUSP00000125003.2, ENSMUST00000136342.9
      Conserved Domains (2) summary
      pfam00906
      Location:626 → 717
      Hepatitis_core; Hepatitis core antigen
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135047795..135080787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164230.1 → XP_036020123.1  serine/arginine repetitive matrix protein 1 isoform X8

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:589 → 786
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    2. XM_030253660.2 → XP_030109520.1  serine/arginine repetitive matrix protein 1 isoform X7

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:593 → 790
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    3. XM_030253661.2 → XP_030109521.1  serine/arginine repetitive matrix protein 1 isoform X9

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03247
      Location:359 → 775
      PHA03247; large tegument protein UL36; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    4. XM_036164229.1 → XP_036020122.1  serine/arginine repetitive matrix protein 1 isoform X6

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:593 → 790
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    5. XM_030253657.2 → XP_030109517.1  serine/arginine repetitive matrix protein 1 isoform X2

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:618 → 815
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    6. XM_030253669.2 → XP_030109529.1  serine/arginine repetitive matrix protein 1 isoform X18

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03247
      Location:384 → 799
      PHA03247; large tegument protein UL36; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    7. XM_030253659.2 → XP_030109519.1  serine/arginine repetitive matrix protein 1 isoform X5

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03247
      Location:384 → 800
      PHA03247; large tegument protein UL36; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    8. XM_006539029.4 → XP_006539092.1  serine/arginine repetitive matrix protein 1 isoform X4

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:609 → 809
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    9. XM_030253658.2 → XP_030109518.1  serine/arginine repetitive matrix protein 1 isoform X3

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:609 → 806
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    10. XM_006539026.4 → XP_006539089.1  serine/arginine repetitive matrix protein 1 isoform X1

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:623 → 820
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:46 → 115
      PWI; PWI domain

    11. XM_030253664.2 → XP_030109524.1  serine/arginine repetitive matrix protein 1 isoform X13

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:536 → 733
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    12. XM_006539033.4 → XP_006539096.1  serine/arginine repetitive matrix protein 1 isoform X10

      See identical proteins and their annotated locations for XP_006539096.1

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:541 → 738
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    13. XM_030253667.2 → XP_030109527.1  serine/arginine repetitive matrix protein 1 isoform X17

      Conserved Domains (1) summary
      PHA03247
      Location:109 → 347
      PHA03247; large tegument protein UL36; Provisional

    14. XM_030253665.2 → XP_030109525.1  serine/arginine repetitive matrix protein 1 isoform X15

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:510 → 707
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    15. XM_036164232.1 → XP_036020125.1  serine/arginine repetitive matrix protein 1 isoform X16

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03247
      Location:276 → 692
      PHA03247; large tegument protein UL36; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    16. XM_017320313.3 → XP_017175802.1  serine/arginine repetitive matrix protein 1 isoform X14

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:511 → 708
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    17. XM_030253663.2 → XP_030109523.1  serine/arginine repetitive matrix protein 1 isoform X13

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:536 → 733
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    18. XM_030253662.2 → XP_030109522.1  serine/arginine repetitive matrix protein 1 isoform X12

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:540 → 737
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    19. XM_036164231.1 → XP_036020124.1  serine/arginine repetitive matrix protein 1 isoform X11

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:540 → 737
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    20. XM_006539032.5 → XP_006539095.1  serine/arginine repetitive matrix protein 1 isoform X10

      See identical proteins and their annotated locations for XP_006539095.1

      UniProtKB/TrEMBL
      E9QKA4
      Conserved Domains (2) summary
      PHA03307
      Location:541 → 738
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam01480
      Location:1 → 32
      PWI; PWI domain

    21. XM_030253666.2 → XP_030109526.1  serine/arginine repetitive matrix protein 1 isoform X17

      Conserved Domains (1) summary
      PHA03247
      Location:109 → 347
      PHA03247; large tegument protein UL36; Provisional

    22. XM_030253668.2 → XP_030109528.1  serine/arginine repetitive matrix protein 1 isoform X17

      Conserved Domains (1) summary
      PHA03247
      Location:109 → 347
      PHA03247; large tegument protein UL36; Provisional

    RNA

    1. XR_004941933.1 RNA Sequence

    2. XR_004941932.1 RNA Sequence

    3. XR_003954981.2 RNA Sequence

    4. XR_004941935.1 RNA Sequence

    5. XR_004941934.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q52KI8.2 GenPept UniProtKB/Swiss-Prot:Q52KI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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