sas stranded at second [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sasprovided by FlyBase
Official Full Name: stranded at secondprovided by FlyBase
Primary source: FLYBASE:FBgn0002306
Locus tag: Dmel_CG2507
See related: AllianceGenome:FB:FBgn0002306
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2507; Dmel\CG2507; l(3)84Cd; rfd; Sas; SAS
Summary: Enables signaling receptor binding activity and structural molecule activity. Involved in axon guidance; cell-cell signaling via exosome; and instar larval development. Located in apical plasma membrane. Is active in extracellular exosome and plasma membrane. Is expressed in several structures, including adult fat body; epithelium; gut section; nerve root; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 84C8-84D1; 3-48 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (7162808..7183702)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (2988600..3009424)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

through a genetic screen in Drosophila, we identify the ligand Sas and the receptor-type tyrosine phosphatase PTP10D as the cell-surface ligand-receptor system that drives tumour-suppressive cell competition
Title: The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition.
The study of this study showed that neuronal Ptp10D restrains signaling by overexpressed glial Sas, which would otherwise produce strong glial and axonal phenotypes.
Title: Interactions between a receptor tyrosine phosphatase and a cell surface ligand regulate axon guidance and glial-neuronal communication.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling via exosome	IDA Inferred from Direct Assay more info	PubMed
involved_in instar larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: stranded at second

Names: CG2507-PA; CG2507-PB; CG2507-PC; CG2507-PD; responsible for dominant phenotype; sas-PA; sas-PB; sas-PC; sas-PD; stranded-at-second

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

7162808..7183702

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275408.2 → NP_001262337.1 stranded at second, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262337.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q04164, Q960M6, Q9VI73

UniProtKB/TrEMBL

A0A0B4KGP7, F0JAM4

Conserved Domains (3) summary

smart00214
Location:752 → 824

VWC; von Willebrand factor (vWF) type C domain

cd00063
Location:1516 → 1605

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:1413 → 1479

fn3; Fibronectin type III domain
NM_001275407.2 → NP_001262336.1 stranded at second, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262336.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFQ8

Conserved Domains (3) summary

smart00214
Location:752 → 824

VWC; von Willebrand factor (vWF) type C domain

cd00063
Location:1171 → 1260

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:1068 → 1134

fn3; Fibronectin type III domain
NM_057263.5 → NP_476611.1 stranded at second, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476611.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFQ8

Related

FBpp0081090

Conserved Domains (3) summary

smart00214
Location:752 → 824

VWC; von Willebrand factor (vWF) type C domain

cd00063
Location:1171 → 1260

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:1068 → 1134

fn3; Fibronectin type III domain
NM_169177.3 → NP_731141.1 stranded at second, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731141.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q04164, Q960M6, Q9VI73

UniProtKB/TrEMBL

A0A0B4KGP7, F0JAM4

Related

FBpp0081089

Conserved Domains (3) summary

smart00214
Location:752 → 824

VWC; von Willebrand factor (vWF) type C domain

cd00063
Location:1516 → 1605

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:1413 → 1479

fn3; Fibronectin type III domain