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    RPT5 proteasome regulatory particle base subunit RPT5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854284, updated on 9-Dec-2024

    Summary

    Official Symbol
    RPT5
    Official Full Name
    proteasome regulatory particle base subunit RPT5
    Primary source
    SGD:S000005643
    Locus tag
    YOR117W
    See related
    AllianceGenome:SGD:S000005643; FungiDB:YOR117W; VEuPathDB:YOR117W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YTA1
    Summary
    Predicted to enable ATP hydrolysis activity and proteasome-activating activity. Involved in positive regulation of RNA polymerase II transcription preinitiation complex assembly; proteasome regulatory particle assembly; and ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle, base subcomplex. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See RPT5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (545029..546333)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Trs33p Neighboring gene DNA-directed RNA polymerase III core subunit RPO31 Neighboring gene Rtc5p Neighboring gene protein kinase RIO1

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity PubMed 
    enables proteasome-activating activity  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in nucleus  
    part_of proteasome complex  
    part_of proteasome regulatory particle, base subcomplex  
    part_of proteasome regulatory particle, base subcomplex PubMed 
    part_of proteasome regulatory particle, base subcomplex  

    General protein information

    Preferred Names
    proteasome regulatory particle base subunit RPT5
    NP_014760.3
    • ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      545029..546333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183536.3 → NP_014760.3  TPA: proteasome regulatory particle base subunit RPT5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014760.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2H6, P33297
      UniProtKB/TrEMBL
      A6ZNW5, B3LJG0, C7GML9, C8ZI79, G2WMZ3, N1NWL4
      Conserved Domains (1) summary
      COG1222
      Location:5 → 434
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
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