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    Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) [ Mus musculus (house mouse) ]

    Gene ID: 19697, updated on 24-Dec-2024

    Summary

    Official Symbol
    Relaprovided by MGI
    Official Full Name
    v-rel reticuloendotheliosis viral oncogene homolog A (avian)provided by MGI
    Primary source
    MGI:MGI:103290
    See related
    Ensembl:ENSMUSG00000024927 AllianceGenome:MGI:103290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p65; p65 NFkB; p65 NF-kappa B
    Summary
    Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; actinin binding activity; and ankyrin repeat binding activity. Involved in several processes, including negative regulation of protein sumoylation; positive regulation of canonical NF-kappaB signal transduction; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; negative regulation of extrinsic apoptotic signaling pathway; and positive regulation of interleukin-12 production. Located in chromatin; cytosol; and nucleus. Part of NF-kappaB p50/p65 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; musculature; and skin. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 78.1), lung adult (RPKM 46.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rela in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5686993..5698162)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5637442..5648134)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5601776-5601959 Neighboring gene ribonuclease H2, subunit C Neighboring gene STARR-positive B cell enhancer ABC_E11011 Neighboring gene K(lysine) acetyltransferase 5 Neighboring gene signal-induced proliferation associated gene 1 Neighboring gene pecanex homolog 3 Neighboring gene microRNA 6987

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 57
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables NF-kappaB binding  
    enables NF-kappaB binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II core promoter sequence-specific DNA binding  
    enables RNA polymerase II core promoter sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding PubMed 
    enables actinin binding PubMed 
    enables actinin binding  
    enables ankyrin repeat binding PubMed 
    enables chromatin DNA binding  
    enables chromatin DNA binding  
    enables chromatin binding PubMed 
    enables chromatin binding  
    enables double-stranded DNA binding  
    enables enzyme binding PubMed 
    enables enzyme binding  
    enables general transcription initiation factor binding  
    enables general transcription initiation factor binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables peptide binding  
    enables peptide binding  
    enables phosphate ion binding  
    enables phosphate ion binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase binding PubMed 
    enables protein kinase binding  
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables transcription cis-regulatory region binding  
    enables transcription coactivator binding  
    enables transcription coactivator binding  
    enables transcription regulator activity PubMed 
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 57
    Items 1 - 25 of 133
    Process Evidence Code Pubs
    involved_in DNA-templated transcription PubMed 
    involved_in acetaldehyde metabolic process  
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    involved_in antiviral innate immune response  
    involved_in antiviral innate immune response  
    involved_in canonical NF-kappaB signal transduction  
    involved_in canonical NF-kappaB signal transduction  
    involved_in cellular response to angiotensin  
    involved_in cellular response to angiotensin  
    acts_upstream_of_or_within cellular response to biotic stimulus PubMed 
    acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus PubMed 
    involved_in cellular response to hydrogen peroxide  
    involved_in cellular response to hydrogen peroxide  
    involved_in cellular response to interleukin-1  
    involved_in cellular response to interleukin-6  
    involved_in cellular response to interleukin-6  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to lipoteichoic acid  
    involved_in cellular response to lipoteichoic acid  
    involved_in cellular response to nicotine  
    involved_in cellular response to nicotine  
    involved_in cellular response to peptidoglycan  
    involved_in cellular response to peptidoglycan  
    involved_in cellular response to tumor necrosis factor  
    involved_in cellular response to tumor necrosis factor  
    involved_in chromatin organization PubMed 
    involved_in cytokine-mediated signaling pathway  
    acts_upstream_of_or_within defense response PubMed 
    involved_in defense response to tumor cell  
    involved_in defense response to tumor cell  
    acts_upstream_of_or_within hair follicle development PubMed 
    involved_in inflammatory response  
    involved_in inflammatory response  
    involved_in inflammatory response  
    involved_in innate immune response  
    involved_in interleukin-1-mediated signaling pathway  
    involved_in interleukin-1-mediated signaling pathway  
    involved_in intracellular signal transduction  
    involved_in liver development PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of insulin receptor signaling pathway  
    involved_in negative regulation of insulin receptor signaling pathway  
    involved_in negative regulation of miRNA transcription  
    involved_in negative regulation of miRNA transcription  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within negative regulation of protein catabolic process PubMed 
    involved_in negative regulation of protein sumoylation PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in neuropeptide signaling pathway  
    involved_in neuropeptide signaling pathway  
    involved_in non-canonical NF-kappaB signal transduction  
    involved_in non-canonical NF-kappaB signal transduction  
    involved_in non-canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of Schwann cell differentiation  
    involved_in positive regulation of Schwann cell differentiation  
    involved_in positive regulation of T cell receptor signaling pathway  
    involved_in positive regulation of T cell receptor signaling pathway  
    acts_upstream_of positive regulation of amyloid-beta formation PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of chondrocyte differentiation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of interleukin-1 beta production  
    acts_upstream_of positive regulation of interleukin-1 beta production  
    acts_upstream_of_or_within positive regulation of interleukin-12 production PubMed 
    involved_in positive regulation of interleukin-6 production  
    acts_upstream_of positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-8 production  
    acts_upstream_of positive regulation of interleukin-8 production  
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell  
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell  
    involved_in positive regulation of miRNA metabolic process  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of vascular endothelial growth factor production  
    involved_in positive regulation of vascular endothelial growth factor production  
    involved_in postsynapse to nucleus signaling pathway  
    involved_in postsynapse to nucleus signaling pathway  
    involved_in prolactin signaling pathway  
    involved_in prolactin signaling pathway  
    acts_upstream_of protein catabolic process PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of inflammatory response PubMed 
    acts_upstream_of_or_within regulation of inflammatory response PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to UV-B  
    involved_in response to UV-B  
    involved_in response to amino acid  
    acts_upstream_of_or_within response to bacterium PubMed 
    involved_in response to cAMP  
    involved_in response to cobalamin  
    involved_in response to cytokine  
    involved_in response to insulin  
    involved_in response to interleukin-1  
    involved_in response to ischemia  
    acts_upstream_of_or_within response to muramyl dipeptide PubMed 
    acts_upstream_of_or_within response to muscle stretch PubMed 
    involved_in response to progesterone  
    involved_in response to xenobiotic stimulus  
    involved_in toll-like receptor 4 signaling pathway  
    involved_in toll-like receptor 4 signaling pathway  
    involved_in toll-like receptor TLR6:TLR2 signaling pathway  
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 133
    Items 1 - 20 of 26
    Component Evidence Code Pubs
    part_of NF-kappaB complex  
    part_of NF-kappaB complex PubMed 
    part_of NF-kappaB p50/p65 complex  
    part_of NF-kappaB p50/p65 complex PubMed 
    part_of NF-kappaB p50/p65 complex  
    part_of NF-kappaB p50/p65 complex PubMed 
    part_of NF-kappaB p50/p65 complex PubMed 
    located_in chromatin PubMed 
    located_in chromatin  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    is_active_in nucleus  
    is_active_in nucleus PubMed 
    located_in nucleus PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    part_of protein-containing complex  
    is_active_in synapse  
    part_of transcription regulator complex PubMed 
    part_of transcription regulator complex  
    part_of transcription regulator complex PubMed 
    Items 1 - 20 of 26

    General protein information

    Preferred Names
    transcription factor p65
    Names
    avian reticuloendotheliosis viral (v-rel) oncogene homolog A
    nuclear factor NF-kappa-B p65 subunit
    nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001365067.1NP_001351996.1  transcription factor p65 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC126029, AC134563
      Conserved Domains (3) summary
      cd01177
      Location:144240
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      cl08275
      Location:93137
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
      cl26464
      Location:205471
      Atrophin-1; Atrophin-1 family
    2. NM_001402548.1NP_001389477.1  transcription factor p65 isoform p65 iso 3

      Status: VALIDATED

      Source sequence(s)
      MN508964
      UniProtKB/TrEMBL
      Q3U3Q8, Q8BTL4
    3. NM_009045.5NP_033071.1  transcription factor p65 isoform 1

      See identical proteins and their annotated locations for NP_033071.1

      Status: VALIDATED

      Source sequence(s)
      AC126029, AC134563
      Consensus CDS
      CCDS29473.1
      UniProtKB/Swiss-Prot
      Q04207, Q62025
      UniProtKB/TrEMBL
      Q3U3Q8, Q548Y4, Q8BTL4
      Related
      ENSMUSP00000025867.6, ENSMUST00000025867.6
      Conserved Domains (2) summary
      cd07885
      Location:19187
      RHD-n_RelA; N-terminal sub-domain of the Rel homology domain (RHD) of RelA
      cd01177
      Location:194290
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5686993..5698162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531694.4XP_006531757.1  transcription factor p65 isoform X1

      UniProtKB/TrEMBL
      Q3U3Q8, Q8BTL4
      Conserved Domains (4) summary
      cd07885
      Location:26194
      RHD-n_RelA; N-terminal sub-domain of the Rel homology domain (RHD) of RelA
      PHA03247
      Location:262528
      PHA03247; large tegument protein UL36; Provisional
      cd01177
      Location:201297
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam17322
      Location:451539
      DUF5364; Family of unknown function (DUF5364)
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