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    STE11 mitogen-activated protein kinase kinase kinase STE11 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851076, updated on 9-Dec-2024

    Summary

    Official Symbol
    STE11
    Official Full Name
    mitogen-activated protein kinase kinase kinase STE11
    Primary source
    SGD:S000004354
    Locus tag
    YLR362W
    See related
    AllianceGenome:SGD:S000004354; FungiDB:YLR362W; VEuPathDB:YLR362W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables MAP kinase kinase kinase activity and SAM domain binding activity. Involved in several processes, including intracellular signal transduction; invasive growth in response to glucose limitation; and pseudohyphal growth. Located in cytoplasm. Orthologous to human MAP3K19 (mitogen-activated protein kinase kinase kinase 19). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See STE11 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (849866..852019)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Vps38p Neighboring gene phosphoprotein phosphatase Neighboring gene uncharacterized protein Neighboring gene Nmd4p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_001144.5

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables JUN kinase kinase kinase activity  
    enables MAP kinase kinase kinase activity PubMed 
    enables SAM domain binding PubMed 
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    Process Evidence Code Pubs
    involved_in JNK cascade  
    involved_in MAPK cascade  
    involved_in cell integrity MAPK cascade PubMed 
    involved_in cellular hyperosmotic response PubMed 
    involved_in cellular hyperosmotic response PubMed 
    involved_in invasive growth in response to glucose limitation PubMed 
    involved_in osmosensory signaling pathway via Sho1 osmosensor PubMed 
    involved_in p38MAPK cascade  
    involved_in p38MAPK cascade PubMed 
    involved_in p38MAPK cascade PubMed 
    involved_in pheromone response MAPK cascade PubMed 
    involved_in pheromone response MAPK cascade PubMed 
    involved_in pheromone response MAPK cascade PubMed 
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion PubMed 
    involved_in pseudohyphal growth PubMed 
    involved_in response to pheromone  
    involved_in signal transduction involved in filamentous growth PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase STE11
    NP_013466.1
    • Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      849866..852019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182251.1 → NP_013466.1  TPA: mitogen-activated protein kinase kinase kinase STE11 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013466.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A1P0, D6VZ00, P23561
      UniProtKB/TrEMBL
      G2WJI0
      Conserved Domains (3) summary
      cd09534
      Location:20 → 82
      SAM_Ste11_fungal; SAM domain of Ste11_fungal subfamily
      pfam14847
      Location:121 → 224
      Ras_bdg_2; Ras-binding domain of Byr2
      cl21453
      Location:415 → 712
      PKc_like; Protein Kinases, catalytic domain
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