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    UFE1 Ufe1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854242, updated on 4-Jan-2025

    Summary

    Official Symbol
    UFE1
    Official Full Name
    Ufe1p
    Primary source
    SGD:S000005601
    Locus tag
    YOR075W
    See related
    AllianceGenome:SGD:S000005601; FungiDB:YOR075W; VEuPathDB:YOR075W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable SNAP receptor activity. Involved in endoplasmic reticulum membrane fusion and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum. Part of SNARE complex. Orthologous to human STX18 (syntaxin 18). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See UFE1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (468212..469252)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Sgo1p Neighboring gene thymidylate synthase Neighboring gene Ski7p Neighboring gene Rts2p

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    part_of SNARE complex  
    part_of SNARE complex PubMed 
    located_in cytoplasm  
    located_in endoplasmic reticulum PubMed 
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in membrane  

    General protein information

    Preferred Names
    Ufe1p
    NP_014718.1
    • t-SNARE protein required for retrograde vesicular traffic; involved in Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      468212..469252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183494.1 → NP_014718.1  TPA: Ufe1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014718.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2D8, P41834
      UniProtKB/TrEMBL
      G2WMV3, N1NYB8
      Conserved Domains (3) summary
      COG5325
      Location:170 → 341
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15850
      Location:258 → 316
      SNARE_syntaxin18; SNARE motif, subgroup Qa
      pfam10496
      Location:4 → 90
      Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus
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