U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 [ Homo sapiens (human) ]

    Gene ID: 55466, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    DNAJA4provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member A4provided by HGNC
    Primary source
    HGNC:HGNC:14885
    See related
    Ensembl:ENSG00000140403 AllianceGenome:HGNC:14885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST104; MSTP104; PRO1472
    Summary
    Enables protein-folding chaperone binding activity and unfolded protein binding activity. Involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Located in cytosol and membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart (RPKM 43.9), testis (RPKM 33.4) and 23 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See DNAJA4 in Genome Data Viewer
    Location:
    15q25.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (78264145..78282191)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (76126705..76144763)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (78556487..78574533)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9911 Neighboring gene isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78500283-78500794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9913 Neighboring gene DNAJA4 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6709 Neighboring gene uncharacterized LOC105370910 Neighboring gene Sharpr-MPRA regulatory region 12554 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:78580466-78580710 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:78591149-78592116 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:78592117-78593083 Neighboring gene SKI8 subunit of superkiller complex Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78611709-78612294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78614637-78615220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:78623995-78624809 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:78632245-78632873 Neighboring gene cellular retinoic acid binding protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. DNA methylation status of DNAJA4 is essential for human erythropoiesis. Zhang H, et al. Epigenomics, 2022 Oct. PMID 36420716
    2. DNAJA4 deficiency enhances NF-kappa B-related growth arrest induced by hyperthermia in human keratinocytes. Sun YZ, et al. J Dermatol Sci, 2018 Sep. PMID 29807809
    3. DnaJA4 is involved in responses to hyperthermia by regulating the expression of F-actin in HaCaT cells. Liu RJ, et al. Chin Med J (Engl), 2020 Sep 9. PMID 32925288, Free PMC Article
    4. DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation. Zhang Q, et al. Cell Death Dis, 2023 Oct 24. PMID 37875476, Free PMC Article
    5. DNAJA4 Promotes the Replication of the Chinese Giant Salamander Iridovirus. Liu Z, et al. Genes (Basel), 2022 Dec 24. PMID 36672799, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation.
      Title: DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation.
    2. DNAJA4 Promotes the Replication of the Chinese Giant Salamander Iridovirus.
      Title: DNAJA4 Promotes the Replication of the Chinese Giant Salamander Iridovirus.
    3. DNA methylation status of DNAJA4 is essential for human erythropoiesis.
      Title: DNA methylation status of DNAJA4 is essential for human erythropoiesis.
    4. DnaJA4 is involved in responses to hyperthermia by regulating the expression of F-actin in HaCaT cells.
      Title: DnaJA4 is involved in responses to hyperthermia by regulating the expression of F-actin in HaCaT cells.
    5. Hyperthermia reduced HaCaT cell proliferation and promoted cytokine expressions responsible for anti-viral activity, mainly through a NF-kB dependent pathway. DNAJA4-deficiency enhanced the activation of NF-kB by hyperthermia in HaCaT cells.
      Title: DNAJA4 deficiency enhances NF-kappa B-related growth arrest induced by hyperthermia in human keratinocytes.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of inclusion body assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    dnaJ homolog subfamily A member 4
    Names
    DnaJ (Hsp40) homolog, subfamily A, member 4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130182.2 → NP_001123654.1  dnaJ homolog subfamily A member 4 isoform 2

      See identical proteins and their annotated locations for NP_001123654.1

      Status: VALIDATED

      Source sequence(s)
      AC090607
      Consensus CDS
      CCDS45316.1
      UniProtKB/Swiss-Prot
      E9PDM9, Q6AW87, Q8N5Z4, Q8N7P2, Q8WW22
      Related
      ENSP00000378321.3, ENST00000394852.8
      Conserved Domains (1) summary
      PTZ00037
      Location:2 → 394
      PTZ00037; DnaJ_C chaperone protein; Provisional

    2. NM_001130183.2 → NP_001123655.1  dnaJ homolog subfamily A member 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC090607, AK096616, AL133096, BC031044, DA561365
      Consensus CDS
      CCDS45317.1
      UniProtKB/Swiss-Prot
      Q8WW22
      UniProtKB/TrEMBL
      Q69YX3
      Related
      ENSP00000413499.2, ENST00000446172.2
      Conserved Domains (4) summary
      PRK14277
      Location:7 → 354
      PRK14277; chaperone protein DnaJ; Provisional
      cd10719
      Location:108 → 174
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:79 → 305
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      cl02542
      Location:9 → 38
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

    3. NM_001387384.1 → NP_001374313.1  dnaJ homolog subfamily A member 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC090607
      Conserved Domains (1) summary
      PTZ00037
      Location:2 → 412
      PTZ00037; DnaJ_C chaperone protein; Provisional

    4. NM_001387385.1 → NP_001374314.1  dnaJ homolog subfamily A member 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC090607
      Consensus CDS
      CCDS45316.1
      UniProtKB/Swiss-Prot
      E9PDM9, Q6AW87, Q8N5Z4, Q8N7P2, Q8WW22
      Conserved Domains (1) summary
      PTZ00037
      Location:2 → 394
      PTZ00037; DnaJ_C chaperone protein; Provisional

    5. NM_001387386.1 → NP_001374315.1  dnaJ homolog subfamily A member 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090607
      Conserved Domains (1) summary
      PTZ00037
      Location:2 → 317
      PTZ00037; DnaJ_C chaperone protein; Provisional

    6. NM_001387387.1 → NP_001374316.1  dnaJ homolog subfamily A member 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC090607
      Conserved Domains (2) summary
      COG0484
      Location:2 → 110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      cl21722
      Location:106 → 144
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    7. NM_001387388.1 → NP_001374317.1  dnaJ homolog subfamily A member 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC090607
      Consensus CDS
      CCDS45316.1
      UniProtKB/Swiss-Prot
      E9PDM9, Q6AW87, Q8N5Z4, Q8N7P2, Q8WW22
      Related
      ENSP00000339581.3, ENST00000343789.7
      Conserved Domains (1) summary
      PTZ00037
      Location:2 → 394
      PTZ00037; DnaJ_C chaperone protein; Provisional

    8. NM_018602.4 → NP_061072.3  dnaJ homolog subfamily A member 4 isoform 1

      See identical proteins and their annotated locations for NP_061072.3

      Status: VALIDATED

      Source sequence(s)
      AC090607, AK096616, AL133096, BC021720, DB047940
      Consensus CDS
      CCDS10299.2
      UniProtKB/Swiss-Prot
      Q8WW22
      UniProtKB/TrEMBL
      Q69YX3
      Related
      ENSP00000378324.3, ENST00000394855.7
      Conserved Domains (4) summary
      cd10719
      Location:164 → 230
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:135 → 361
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:15 → 423
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:36 → 94
      DnaJ; DnaJ domain

    RNA

    1. NR_170653.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090607

    2. NR_170654.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090607

    3. NR_170655.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090607

    4. NR_170656.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090607

    5. NR_170657.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090607

    6. NR_170658.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090607

    7. NR_170666.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090607

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      78264145..78282191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432836.1 → XP_047288792.1  dnaJ homolog subfamily A member 4 isoform X2

    2. XM_047432834.1 → XP_047288790.1  dnaJ homolog subfamily A member 4 isoform X1

    3. XM_047432835.1 → XP_047288791.1  dnaJ homolog subfamily A member 4 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      76126705..76144763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378417.1 → XP_054234392.1  dnaJ homolog subfamily A member 4 isoform X2

    2. XM_054378416.1 → XP_054234391.1  dnaJ homolog subfamily A member 4 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WW22.1 GenPept UniProtKB/Swiss-Prot:Q8WW22

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools