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    SLIT3 slit guidance ligand 3 [ Bos taurus (domestic cattle) ]

    Gene ID: 615883, updated on 27-Dec-2024

    Summary

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    Official Symbol
    SLIT3provided by VGNC
    Official Full Name
    slit guidance ligand 3provided by VGNC
    Primary source
    VGNC:VGNC:34961
    See related
    Ensembl:ENSBTAG00000017746
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SLIT3 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (442969..1201675, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-103-1 Neighboring gene spermatogenic leucine zipper 1 Neighboring gene pantothenate kinase 3 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene microRNA mir-218-2 Neighboring gene uncharacterized LOC107131552 Neighboring gene microRNA mir-2285ct Neighboring gene uncharacterized LOC132343198 Neighboring gene uncharacterized LOC104975179 Neighboring gene spindle apparatus coiled-coil protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables Roundabout binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    slit homolog 3 protein
    Names
    slit homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191450.1 → NP_001178379.1  slit homolog 3 protein precursor

      Status: PROVISIONAL

      Source sequence(s)
      DT810788, DV892950, EH169894, EH175483, NKLS02000020
      UniProtKB/TrEMBL
      A0AAA9S249, F1MMM6
      Related
      ENSBTAP00000046486.4, ENSBTAT00000049620.5
      Conserved Domains (12) summary
      smart00013
      Location:677 → 708
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:809 → 858
      LRRCT; Leucine rich repeat C-terminal domain
      cd00054
      Location:1026 → 1062
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00116
      Location:49 → 172
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:486 → 510
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:1075 → 1105
      EGF; EGF-like domain
      pfam01462
      Location:33 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      pfam02210
      Location:1140 → 1266
      Laminin_G_2; Laminin G domain
      pfam12799
      Location:283 → 323
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:727 → 787
      LRR_8; Leucine rich repeat
      cl15307
      Location:389 → 419
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl21545
      Location:1418 → 1471
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      442969..1201675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059878791.1 → XP_059734774.1  slit homolog 3 protein isoform X3

      UniProtKB/TrEMBL
      A0AAA9TBI4

    2. XM_024981391.2 → XP_024837159.1  slit homolog 3 protein isoform X1

      UniProtKB/TrEMBL
      A0AAA9S249
      Conserved Domains (11) summary
      TIGR00864
      Location:636 → 714
      PCC; polycystin cation channel protein
      smart00013
      Location:725 → 756
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:62 → 220
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00054
      Location:1074 → 1110
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:1159 → 1312
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      sd00033
      Location:64 → 86
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:1123 → 1153
      EGF; EGF-like domain
      pfam13855
      Location:775 → 835
      LRR_8; Leucine rich repeat
      cl15307
      Location:215 → 250
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
      cl21545
      Location:1466 → 1519
      GHB_like; Glycoprotein hormone beta chain homologues
      cl26018
      Location:255 → 377
      NEL; C-terminal novel E3 ligase, LRR-interacting

    3. XM_059878790.1 → XP_059734773.1  slit homolog 3 protein isoform X2

      UniProtKB/TrEMBL
      A0AAA9TBI4
    Nucleotide Protein Strain
    Heading Accession and Version

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