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    SUP45 translation termination factor eRF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852440, updated on 9-Dec-2024

    Summary

    Official Symbol
    SUP45
    Official Full Name
    translation termination factor eRF1
    Primary source
    SGD:S000000347
    Locus tag
    YBR143C
    See related
    AllianceGenome:SGD:S000000347; FungiDB:YBR143C; VEuPathDB:YBR143C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SAL4; SUP1; SUP47
    Summary
    Enables translation release factor activity, codon specific. Involved in DNA-templated transcription termination; sno(s)RNA transcription; and translational termination. Located in cytoplasmic stress granule. Part of translation release factor complex. Orthologous to human ETF1 (eukaryotic translation termination factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See SUP45 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (530869..532182, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene 25S rRNA (adenine2142-N1)-methyltransferase Neighboring gene putative ATP-dependent RNA helicase Neighboring gene uncharacterized protein Neighboring gene alcohol dehydrogenase ADH5

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Process Evidence Code Pubs
    involved_in DNA-templated transcription termination PubMed 
    involved_in RNA metabolic process  
    involved_in cytoplasmic translational termination  
    involved_in gene expression  
    involved_in sno(s)RNA transcription PubMed 
    involved_in translation  
    involved_in translational termination PubMed 
    involved_in translational termination  
    involved_in translational termination PubMed 
    involved_in translational termination PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasmic stress granule PubMed 
    is_active_in cytosol  
    part_of translation release factor complex  
    part_of translation release factor complex PubMed 

    General protein information

    Preferred Names
    translation termination factor eRF1
    NP_009701.3
    • Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      530869..532182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178491.3 → NP_009701.3  TPA: translation termination factor eRF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009701.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQD9, P12385
      UniProtKB/TrEMBL
      A6ZL86, B3LN14, B5VEA0, C7GY25, D3UEN8, G2W9E6, N1P6R7
      Conserved Domains (1) summary
      TIGR03676
      Location:10 → 412
      aRF1/eRF1; peptide chain release factor 1, archaeal and eukaryotic forms
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