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    mig-2 Ras-related C3 botulinum toxin substrate 1;Signal recognition particle protein [ Caenorhabditis elegans ]

    Gene ID: 181344, updated on 9-Dec-2024

    Summary

    Official Symbol
    mig-2
    Official Full Name
    Ras-related C3 botulinum toxin substrate 1;Signal recognition particle protein
    Primary source
    WormBase:WBGene00003239
    Locus tag
    CELE_C35C5.4
    See related
    AllianceGenome:WB:WBGene00003239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activity and protein kinase binding activity. Involved in several processes, including actin cytoskeleton organization; axon guidance; and engulfment of apoptotic cell. Located in cytoplasm; cytoplasmic side of plasma membrane; and neuron projection. Is expressed in several structures, including distal tip cell; linker cell; neurons; somatic gonad precursor; and vulval cell. Used to study epilepsy. Orthologous to human RHOG (ras homolog family member G). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See mig-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (11548608..11550692)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Thioredoxin reductase-like selenoprotein T homolog selt-1.1 Neighboring gene ncRNA Neighboring gene Transmembrane protein 164

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables GTPase activity  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding PubMed 
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in JNK cascade PubMed 
    involved_in actin filament organization  
    involved_in actin filament organization PubMed 
    involved_in axon extension involved in axon guidance PubMed 
    involved_in cell migration PubMed 
    involved_in chemorepulsion of axon PubMed 
    involved_in dorsal/ventral axon guidance PubMed 
    involved_in engulfment of apoptotic cell PubMed 
    involved_in establishment or maintenance of actin cytoskeleton polarity PubMed 
    involved_in innate immune response PubMed 
    involved_in mesodermal cell migration PubMed 
    involved_in motor neuron axon guidance PubMed 
    involved_in negative regulation of microtubule polymerization PubMed 
    involved_in nematode male tail tip morphogenesis PubMed 
    involved_in netrin-activated signaling pathway PubMed 
    involved_in neuron migration PubMed 
    involved_in neuron migration PubMed 
    involved_in neuron projection morphogenesis PubMed 
    involved_in organelle organization  
    involved_in protein localization to cell leading edge PubMed 
    involved_in regulation of dorsal/ventral axon guidance PubMed 
    involved_in regulation of dorsal/ventral axon guidance PubMed 
    involved_in regulation of protein phosphorylation PubMed 
    involved_in regulation of synaptic transmission, GABAergic PubMed 
    involved_in response to copper ion PubMed 
    involved_in signal transduction  
    involved_in small GTPase-mediated signal transduction  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasmic side of plasma membrane PubMed 
    located_in neuron projection PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    Ras-related C3 botulinum toxin substrate 1;Signal recognition particle protein
    NP_001300334.1
    • Confirmed by transcript evidence
    NP_509931.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11548608..11550692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077530.5 → NP_509931.1  Ras-related C3 botulinum toxin substrate 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBV3
      Conserved Domains (2) summary
      smart00174
      Location:10 → 183
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd00157
      Location:8 → 178
      Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)
    2. NM_001313405.4 → NP_001300334.1  Signal recognition particle protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AYI6
      Conserved Domains (1) summary
      cl21455
      Location:1 → 66
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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