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    KIP2 Kip2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855948, updated on 4-Jan-2025

    Summary

    Official Symbol
    KIP2
    Official Full Name
    Kip2p
    Primary source
    SGD:S000006076
    Locus tag
    YPL155C
    See related
    AllianceGenome:SGD:S000006076; FungiDB:YPL155C; VEuPathDB:YPL155C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables microtubule plus end polymerase; plus-end-directed microtubule motor activity; and tubulin binding activity. Involved in microtubule polymerization; negative regulation of microtubule depolymerization; and nuclear migration along microtubule. Located in cortical microtubule plus-end and spindle pole body. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See KIP2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (257216..259336, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene RNA methyltransferase Neighboring gene pheromone-regulated protein PRM4 Neighboring gene proteinase A Neighboring gene serine/threonine/tyrosine protein kinase RAD53

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables cytoskeletal motor activity  
    enables microtubule binding  
    enables microtubule binding  
    enables microtubule motor activity  
    enables microtubule motor activity  
    enables microtubule plus end polymerase PubMed 
    enables microtubule plus end polymerase PubMed 
    enables plus-end-directed microtubule motor activity PubMed 
    enables plus-end-directed microtubule motor activity PubMed 
    enables tubulin binding PubMed 
    enables tubulin binding PubMed 
    Component Evidence Code Pubs
    located_in cortical microtubule plus-end PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic microtubule PubMed 
    located_in cytoskeleton  
    part_of kinesin complex  
    part_of kinesin complex PubMed 
    is_active_in microtubule  
    located_in microtubule  
    located_in mitochondrion PubMed 
    located_in spindle pole body PubMed 

    General protein information

    Preferred Names
    Kip2p
    NP_015170.1
    • Kinesin-related motor protein and plus-end directed microtubule (MT) polymerase; involved in mitotic spindle positioning, nuclear migration, microtubule polymerization and inhibition of MT catastrophe; stabilizes microtubules by targeting Bik1p to the MT plus end; Kip2p levels are controlled during the cell cycle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      257216..259336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183969.1 → NP_015170.1  TPA: Kip2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3L3, P28743
      UniProtKB/TrEMBL
      A6ZW98, B3LKS2, C7GJA7, C8ZIM3, N1NW11
      Conserved Domains (2) summary
      TIGR02168
      Location:445 → 698
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01374
      Location:102 → 493
      KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
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