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    Prps Phosphoribosyl pyrophosphate synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39132, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prpsprovided by FlyBase
    Official Full Name
    Phosphoribosyl pyrophosphate synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036030
    Locus tag
    Dmel_CG6767
    See related
    AllianceGenome:FB:FBgn0036030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6767; Dmel\CG6767; PRPS
    Summary
    Predicted to enable ribose phosphate diphosphokinase activity. Involved in olfactory behavior. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; adult heart; embryonic anal pad; larval muscle cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1); and PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prps in Genome Data Viewer
    Location:
    67C4-67C5; 3-31 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9683579..9696700, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9676679..9689800, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene alpha-Tubulin at 67C Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45804 Neighboring gene antisense RNA:CR45121 Neighboring gene Ubiquitin conjugating enzyme 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribose phosphate diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribose phosphate diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribose phosphate diphosphokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    phosphoribosyl pyrophosphate synthetase
    Names
    CG6767-PA
    CG6767-PB
    CG6767-PC
    CG6767-PD
    CG6767-PF
    CG6767-PG
    CG6767-PH
    CG6767-PI
    CG6767-PJ
    Prps-PA
    Prps-PB
    Prps-PC
    Prps-PD
    Prps-PF
    Prps-PG
    Prps-PH
    Prps-PI
    Prps-PJ
    NP_001261640.1
    • unusual splice
    NP_001261641.1
    NP_001261643.1
    • unusual splice
    NP_001261644.1
    NP_001287010.1
    NP_001287011.1
    NP_001287012.1
    • unusual splice
    NP_648345.1
    NP_729528.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9683579..9696700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140088.3NP_648345.1  phosphoribosyl pyrophosphate synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGE6, Q8SYI6, Q9VT32
      Related
      FBpp0076144
      Conserved Domains (1) summary
      COG0462
      Location:33345
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    2. NM_001274711.1NP_001261640.1  phosphoribosyl pyrophosphate synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEY1, Q8IGE6
      Conserved Domains (1) summary
      COG0462
      Location:33349
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    3. NM_001274715.1NP_001261644.1  phosphoribosyl pyrophosphate synthetase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261644.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF46, Q8IGE6
      Conserved Domains (1) summary
      COG0462
      Location:33368
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    4. NM_001274714.1NP_001261643.1  phosphoribosyl pyrophosphate synthetase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEP5, Q8IGE6
      Conserved Domains (1) summary
      COG0462
      Location:48364
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    5. NM_001274712.1NP_001261641.1  phosphoribosyl pyrophosphate synthetase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHW7, Q8IGE6
      Conserved Domains (1) summary
      COG0462
      Location:48368
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    6. NM_168360.2NP_729528.2  phosphoribosyl pyrophosphate synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729528.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGE6, Q9VT33
      Related
      FBpp0076145
      Conserved Domains (1) summary
      COG0462
      Location:48383
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    7. NM_001300081.1NP_001287010.1  phosphoribosyl pyrophosphate synthetase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287010.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGE6, Q8SYI6, Q9VT32
      Conserved Domains (1) summary
      COG0462
      Location:33345
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    8. NM_001300083.1NP_001287012.1  phosphoribosyl pyrophosphate synthetase, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287012.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEY1, Q8IGE6
      Conserved Domains (1) summary
      COG0462
      Location:33349
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    9. NM_001300082.1NP_001287011.1  phosphoribosyl pyrophosphate synthetase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287011.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF46, Q8IGE6
      Conserved Domains (1) summary
      COG0462
      Location:33368
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]