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    Itpk1 inositol 1,3,4-triphosphate 5/6 kinase [ Mus musculus (house mouse) ]

    Gene ID: 217837, updated on 27-Nov-2024

    Summary

    Official Symbol
    Itpk1provided by MGI
    Official Full Name
    inositol 1,3,4-triphosphate 5/6 kinaseprovided by MGI
    Primary source
    MGI:MGI:2446159
    See related
    Ensembl:ENSMUSG00000057963 AllianceGenome:MGI:2446159
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable inositol phosphate kinase activity. Acts upstream of or within neural tube development. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and peripheral nervous system. Orthologous to human ITPK1 (inositol-tetrakisphosphate 1-kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in duodenum adult (RPKM 120.5), large intestine adult (RPKM 112.0) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Itpk1 in Genome Data Viewer
    Location:
    12 E; 12 51.69 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (102534842..102671128, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (102568583..102704869, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33098 Neighboring gene golgin A5 Neighboring gene STARR-seq mESC enhancer starr_33099 Neighboring gene chromogranin A Neighboring gene VISTA enhancer mm491 Neighboring gene microRNA 1936 Neighboring gene STARR-seq mESC enhancer starr_33110 Neighboring gene STARR-seq mESC enhancer starr_33116 Neighboring gene predicted gene, 30296 Neighboring gene STARR-positive B cell enhancer ABC_E9862 Neighboring gene predicted gene 20604 Neighboring gene modulator of apoptosis 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Potential readthrough

    Included gene: Gon7

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables inositol-1,3,4-trisphosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol-1,3,4-trisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol-1,3,4-trisphosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol-1,3,4-trisphosphate 6-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol-1,3,4-trisphosphate 6-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol-1,3,4-trisphosphate 6-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol-3,4,5,6-tetrakisphosphate 1-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol-3,4,5,6-tetrakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol-3,4,5,6-tetrakisphosphate 1-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol-3,4,6-trisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in inositol trisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in necroptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neural tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inositol-tetrakisphosphate 1-kinase
    Names
    inositol 1,3,4-trisphosphate 5/6-kinase
    inositol-triphosphate 5/6-kinase
    ins(1,3,4)P(3) 5/6-kinase
    NP_766172.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172584.3NP_766172.1  inositol-tetrakisphosphate 1-kinase

      See identical proteins and their annotated locations for NP_766172.1

      Status: PROVISIONAL

      Source sequence(s)
      AC132315, AC156033
      Consensus CDS
      CCDS26121.1
      UniProtKB/Swiss-Prot
      Q8BYN3, Q8K0J6, Q8R0Z0
      Related
      ENSMUSP00000046027.6, ENSMUST00000046518.12
      Conserved Domains (1) summary
      cl17255
      Location:1318
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      102534842..102671128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)