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    St3 Sulfotransferase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St3provided by FlyBase
    Official Full Name
    Sulfotransferase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0265052
    Locus tag
    Dmel_CG44167
    See related
    AllianceGenome:FB:FBgn0265052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11293; CG44167; CG5431; Dmel\CG44167; dmST3; st3
    Old locus tag
    Dmel_CG11293; Dmel_CG5431
    Summary
    Enables sulfotransferase activity. Involved in defense response to bacterium; sulfation; and xenobiotic metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic Malpighian tubule; embryonic esophagus; and embryonic proventriculus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital ichthyosis 14; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1A3 (sulfotransferase family 1A member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See St3 in Genome Data Viewer
    Location:
    59F6-59F6; 2-104 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23683377..23687980)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19570900..19575503)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Phosphodiesterase 8 Neighboring gene Sulfotransferase 1 Neighboring gene lethal (2) essential for life Neighboring gene Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2 Neighboring gene uncharacterized protein Neighboring gene angel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and characterization of cytosolic sulfotransferase isozymes from Drosophila melanogaster. Hattori K, et al. Biosci Biotechnol Biochem, 2008 Feb. PMID 18256476
    2. Expression analysis of a family of developmentally-regulated cytosolic sulfotransferases (SULTs) in Drosophila. Fahmy K, et al. Hereditas, 2013 Jun. PMID 23865965
    3. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Ayres JS, et al. Genetics, 2008 Mar. PMID 18245331, Free PMC Article
    4. Transcriptional regulation by CHIP/LDB complexes. Bronstein R, et al. PLoS Genet, 2010 Aug 12. PMID 20730086, Free PMC Article
    5. Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination. Gao Y, et al. Mol Cell, 2022 Apr 7. PMID 35325613

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfotransferase 3
    Names
    CG44167-PA
    CG44167-PB
    CG44167-PC
    St3-PA
    St3-PB
    St3-PC
    NP_001137744.1
    NP_001261155.1
    NP_611816.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23683377..23687980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274226.1 → NP_001261155.1  sulfotransferase 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261155.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF40
      Conserved Domains (1) summary
      pfam00685
      Location:45 → 301
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_137972.4 → NP_611816.2  sulfotransferase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611816.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL86, Q9W1L7
      Related
      FBpp0307659
      Conserved Domains (1) summary
      pfam00685
      Location:45 → 301
      Sulfotransfer_1; Sulfotransferase domain

    3. NM_001144272.3 → NP_001137744.1  sulfotransferase 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZP4, Q6NL86
      Conserved Domains (1) summary
      pfam00685
      Location:45 → 301
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF40 A0A0B4KF40
    B7YZP4 B7YZP4
    Q8MRH3 Q8MRH3
    Q9W1L7 Q9W1L7

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