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    RRP6 exosome nuclease subunit RRP6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854162, updated on 4-Jan-2025

    Summary

    Official Symbol
    RRP6
    Official Full Name
    exosome nuclease subunit RRP6
    Primary source
    SGD:S000005527
    Locus tag
    YOR001W
    See related
    AllianceGenome:SGD:S000005527; FungiDB:YOR001W; VEuPathDB:YOR001W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3'-5'-RNA exonuclease activity and rRNA primary transcript binding activity. Involved in RNA metabolic process; post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery; and regulation of telomere maintenance. Located in nucleolus. Part of nuclear exosome (RNase complex). Orthologous to human EXOSC10 (exosome component 10). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See RRP6 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (326832..329033)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene PAQR-type receptor Neighboring gene Pho80p Neighboring gene dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Neighboring gene putative subtilisin-like protease YSP3

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_001147.6

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity  
    enables 3'-5'-RNA exonuclease activity PubMed 
    enables 3'-5'-RNA exonuclease activity  
    enables RNA binding  
    enables exonuclease activity  
    enables nucleic acid binding  
    enables nucleotide binding  
    enables rRNA primary transcript binding PubMed 
    enables single-stranded RNA binding  
    enables zinc ion binding PubMed 
    Items 1 - 25 of 34
    Process Evidence Code Pubs
    involved_in TRAMP-dependent tRNA surveillance pathway  
    involved_in TRAMP-dependent tRNA surveillance pathway PubMed 
    involved_in TRAMP-dependent tRNA surveillance pathway PubMed 
    involved_in U1 snRNA 3'-end processing PubMed 
    involved_in U1 snRNA 3'-end processing PubMed 
    involved_in U4 snRNA 3'-end processing PubMed 
    involved_in U4 snRNA 3'-end processing PubMed 
    involved_in U5 snRNA 3'-end processing PubMed 
    involved_in U5 snRNA 3'-end processing PubMed 
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) PubMed 
    involved_in histone mRNA catabolic process  
    involved_in histone mRNA catabolic process PubMed 
    involved_in nuclear mRNA surveillance PubMed 
    involved_in nuclear mRNA surveillance PubMed 
    involved_in nuclear polyadenylation-dependent CUT catabolic process  
    involved_in nuclear polyadenylation-dependent CUT catabolic process PubMed 
    involved_in nuclear polyadenylation-dependent CUT catabolic process PubMed 
    involved_in nuclear polyadenylation-dependent antisense transcript catabolic process  
    involved_in nuclear polyadenylation-dependent antisense transcript catabolic process PubMed 
    involved_in nuclear polyadenylation-dependent mRNA catabolic process PubMed 
    involved_in nuclear polyadenylation-dependent rRNA catabolic process  
    involved_in nuclear polyadenylation-dependent rRNA catabolic process PubMed 
    involved_in nuclear polyadenylation-dependent rRNA catabolic process PubMed 
    involved_in nuclear polyadenylation-dependent snRNA catabolic process  
    involved_in nuclear polyadenylation-dependent snRNA catabolic process PubMed 
    involved_in nuclear polyadenylation-dependent snoRNA catabolic process  
    involved_in nuclear polyadenylation-dependent snoRNA catabolic process PubMed 
    involved_in poly(A)-dependent snoRNA 3'-end processing  
    involved_in poly(A)-dependent snoRNA 3'-end processing PubMed 
    involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery PubMed 
    involved_in rRNA processing  
    involved_in regulation of telomere maintenance PubMed 
    Items 1 - 25 of 34
    Component Evidence Code Pubs
    part_of exosome (RNase complex)  
    part_of nuclear exosome (RNase complex)  
    part_of nuclear exosome (RNase complex) PubMed 
    part_of nuclear exosome (RNase complex)  
    is_active_in nucleolus  
    located_in nucleolus PubMed 
    located_in nucleolus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    exosome nuclease subunit RRP6
    NP_014643.1
    • Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      326832..329033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183420.1 → NP_014643.1  TPA: exosome nuclease subunit RRP6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014643.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W267, Q12149, Q6B280
      UniProtKB/TrEMBL
      A6ZNK6, B3LJ56, B5VRQ3, C7GJV2, C8ZHW4
      Conserved Domains (3) summary
      cd06147
      Location:209 → 399
      Rrp6p_like_exo; DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins
      COG0349
      Location:216 → 622
      Rnd; Ribonuclease D [Translation, ribosomal structure and biogenesis]
      pfam08066
      Location:17 → 100
      PMC2NT; PMC2NT (NUC016) domain
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