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    prp-17 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172999, updated on 9-Dec-2024

    Summary

    Official Symbol
    prp-17
    Official Full Name
    WD_REPEATS_REGION domain-containing protein
    Primary source
    WormBase:WBGene00018625
    Locus tag
    CELE_F49D11.1
    See related
    AllianceGenome:WB:WBGene00018625
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 15. Orthologous to human CDC40 (cell division cycle 40). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See prp-17 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (10936815..10940521)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Glycolipid transfer protein domain-containing protein Neighboring gene Transmembrane protein Neighboring gene BZIP domain-containing protein Neighboring gene Large ribosomal subunit protein mL52

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA binding  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome  
    involved_in mRNA splicing, via spliceosome  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome  
    part_of catalytic step 2 spliceosome  

    General protein information

    Preferred Names
    WD_REPEATS_REGION domain-containing protein
    NP_492851.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10936815..10940521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060450.6 → NP_492851.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492851.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44729
      Conserved Domains (2) summary
      cd00200
      Location:267 → 567
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:279 → 317
      7WD40; WD40 repeat [structural motif]
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