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    cam-1 Tyrosine-protein kinase receptor cam-1 [ Caenorhabditis elegans ]

    Gene ID: 174473, updated on 9-Dec-2024

    Summary

    Official Symbol
    cam-1
    Official Full Name
    Tyrosine-protein kinase receptor cam-1
    Primary source
    WormBase:WBGene00000289
    Locus tag
    CELE_C01G6.8
    See related
    AllianceGenome:WB:WBGene00000289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables Wnt-protein binding activity; frizzled binding activity; and transmembrane receptor protein tyrosine kinase activity. Involved in generation of neurons and neuroblast migration. Located in several cellular components, including dendrite; neuromuscular junction; and neuronal cell body membrane. Is expressed in several structures, including QL; head; hypodermis; neurons; and pharynx. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; autosomal recessive nonsyndromic deafness 108; brachydactyly type B1; and cleft palate. Orthologous to several human genes including ROR1 (receptor tyrosine kinase like orphan receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See cam-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (9295915..9310304, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Acyl-CoA synthetase 7 Neighboring gene Golgi apparatus protein 1 Neighboring gene ncRNA Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene WD repeat and FYVE domain-containing protein 2

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables Wnt-protein binding  
    enables Wnt-protein binding PubMed 
    enables frizzled binding PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein kinase activity  
    enables protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity PubMed 
    enables transmembrane receptor protein tyrosine kinase activity  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway  
    involved_in anatomical structure morphogenesis  
    involved_in axon guidance PubMed 
    involved_in cell migration PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in establishment of neuroblast polarity PubMed 
    involved_in interneuron migration PubMed 
    involved_in motor neuron migration PubMed 
    involved_in multicellular organism development  
    involved_in nervous system development  
    involved_in neuroblast migration PubMed 
    involved_in neuron migration PubMed 
    involved_in neurotrophin signaling pathway  
    involved_in protein phosphorylation  
    involved_in sensory neuron migration PubMed 
    involved_in sensory neuron migration PubMed 
    Component Evidence Code Pubs
    is_active_in axon  
    located_in axon PubMed 
    located_in axon  
    located_in cell projection PubMed 
    located_in cell projection  
    located_in dendrite PubMed 
    located_in dendrite  
    located_in neuromuscular junction PubMed 
    located_in neuron projection PubMed 
    located_in neuronal cell body membrane PubMed 
    located_in perikaryon  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    part_of receptor complex  
    located_in synapse  

    General protein information

    Preferred Names
    Tyrosine-protein kinase receptor cam-1
    NP_001021907.1
    • Confirmed by transcript evidence
    NP_001021908.1
    • Confirmed by transcript evidence
    NP_001379452.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9295915..9310304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393151.1 → NP_001379452.1  Tyrosine-protein kinase receptor cam-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      cd07459
      Location:44 → 176
      CRD_TK_ROR_like; Cysteine-rich domain of tyrosine kinase-like orphan receptors
      smart00130
      Location:193 → 272
      KR; Kringle domain
      cd00192
      Location:435 → 699
      PTKc; Catalytic domain of Protein Tyrosine Kinases
    2. NM_001026736.5 → NP_001021907.1  Tyrosine-protein kinase receptor cam-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021907.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECA5, G5EGK5, Q38G54
      Conserved Domains (6) summary
      cd00096
      Location:55 → 122
      Ig; Immunoglobulin domain
      cd07459
      Location:203 → 335
      CRD_TK_ROR_like; Cysteine-rich domain of tyrosine kinase-like orphan receptors
      smart00130
      Location:352 → 431
      KR; Kringle domain
      smart00221
      Location:590 → 857
      STYKc; Protein kinase; unclassified specificity
      pfam07679
      Location:39 → 127
      I-set; Immunoglobulin I-set domain
      cd00192
      Location:594 → 858
      PTKc; Catalytic domain of Protein Tyrosine Kinases
    3. NM_001026737.6 → NP_001021908.1  Tyrosine-protein kinase receptor cam-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EGK5
      Conserved Domains (6) summary
      cd00096
      Location:29 → 96
      Ig; Immunoglobulin domain
      cd07459
      Location:177 → 309
      CRD_TK_ROR_like; Cysteine-rich domain of tyrosine kinase-like orphan receptors
      smart00130
      Location:326 → 405
      KR; Kringle domain
      smart00221
      Location:564 → 831
      STYKc; Protein kinase; unclassified specificity
      pfam07679
      Location:13 → 101
      I-set; Immunoglobulin I-set domain
      cd00192
      Location:568 → 832
      PTKc; Catalytic domain of Protein Tyrosine Kinases
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