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    dve-1 Homeobox protein dve-1 [ Caenorhabditis elegans ]

    Gene ID: 180398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dve-1
    Official Full Name
    Homeobox protein dve-1
    Primary source
    WormBase:WBGene00022861
    Locus tag
    CELE_ZK1193.5
    See related
    AllianceGenome:WB:WBGene00022861
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; enzyme binding activity; and protein-folding chaperone binding activity. Involved in embryo development; mitochondrial unfolded protein response; and regulation of innate immune response. Located in chromatin; cytosol; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including arcade cell; intestine; midbody; nervous system; and rectum. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to human SATB1 (SATB homeobox 1) and SATB2 (SATB homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dve-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (427035..433812, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene VWFA domain-containing protein Neighboring gene tRNA-Gln Neighboring gene Cuticle collagen 19 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysosomal dysfunction by inactivation of V-ATPase drives innate immune response in C. elegans. Pu X, et al. Cell Rep, 2024 May 28. PMID 38678555
    2. The homeodomain transcriptional regulator DVE-1 directs a program for synapse elimination during circuit remodeling. Alexander KD, et al. Nat Commun, 2023 Nov 18. PMID 37980357, Free PMC Article
    3. The UPR(mt) Protects Caenorhabditis elegans from Mitochondrial Dysfunction by Upregulating Specific Enzymes of the Mevalonate Pathway. Oks O, et al. Genetics, 2018 Jun. PMID 29599115, Free PMC Article
    4. The mitochondrial unfolded protein response: A multitasking giant in the fight against human diseases. Zhou Z, et al. Ageing Res Rev, 2022 Nov. PMID 35908669
    5. Mitochondrial Unfolded Protein Response to Microgravity Stress in Nematode Caenorhabditis elegans. Liu P, et al. Sci Rep, 2019 Nov 11. PMID 31712608, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Homeobox protein dve-1
    NP_001024984.1
    • Confirmed by transcript evidence
    NP_001338861.1
    • Confirmed by transcript evidence
    NP_001370744.1
    • Confirmed by transcript evidence
    NP_001380218.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      427035..433812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392715.1 → NP_001380218.1  Homeobox protein dve-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      smart00389
      Location:176 → 241
      HOX; Homeodomain

    2. NM_001383518.2 → NP_001370744.1  Homeobox protein dve-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      smart00389
      Location:179 → 244
      HOX; Homeodomain

    3. NM_001029813.7 → NP_001024984.1  Homeobox protein dve-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024984.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1X7RBT0, A0A1X7RBW4, Q86MH8, Q86MI0
      Conserved Domains (2) summary
      smart00389
      Location:387 → 452
      HOX; Homeodomain
      cd11585
      Location:2 → 100
      SATB1_N; N-terminal domain of SATB1 and similar proteins

    4. NM_001351875.4 → NP_001338861.1  Homeobox protein dve-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      smart00389
      Location:384 → 449
      HOX; Homeodomain
      cd11585
      Location:2 → 100
      SATB1_N; N-terminal domain of SATB1 and similar proteins

    RNA

    1. NR_147826.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86MI0.1

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