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    Coq6 coenzyme Q6 monooxygenase [ Mus musculus (house mouse) ]

    Gene ID: 217707, updated on 9-Dec-2024

    Summary

    Official Symbol
    Coq6provided by MGI
    Official Full Name
    coenzyme Q6 monooxygenaseprovided by MGI
    Primary source
    MGI:MGI:1924408
    See related
    Ensembl:ENSMUSG00000021235 AllianceGenome:MGI:1924408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5930427M12Rik
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in epididymis; heart; heart right ventricle; metanephros; and testis. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 6. Orthologous to human COQ6 (coenzyme Q6, monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 30.2), adrenal adult (RPKM 26.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Coq6 in Genome Data Viewer
    Location:
    12 D1; 12 39.18 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84408530..84420570)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84361756..84373796)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10765 Neighboring gene prostaglandin reductase 2 Neighboring gene zinc finger protein 410 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene family with sequence similarity 161, member B Neighboring gene STARR-positive B cell enhancer ABC_E1445 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:85729760-85729947 Neighboring gene STARR-positive B cell enhancer ABC_E8493 Neighboring gene basal body orientation factor 1 Neighboring gene ring finger protein 113A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquinone biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extrinsic component of mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquinone biosynthesis complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquinone biosynthesis complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
    Names
    coenzyme Q10 monooxygenase 6
    coenzyme Q6 homolog
    NP_766170.2
    XP_006515762.1
    XP_006515763.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172582.3NP_766170.2  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial precursor

      See identical proteins and their annotated locations for NP_766170.2

      Status: VALIDATED

      Source sequence(s)
      AC120402, BC132170
      Consensus CDS
      CCDS26044.1
      UniProtKB/Swiss-Prot
      Q3TJM2, Q80V13, Q8BJY5, Q8R1S0
      UniProtKB/TrEMBL
      D3YW66
      Related
      ENSMUSP00000021661.7, ENSMUST00000021661.13
      Conserved Domains (1) summary
      cl21454
      Location:57471
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84408530..84420570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515699.2XP_006515762.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006515762.1

      UniProtKB/Swiss-Prot
      Q3TJM2, Q80V13, Q8BJY5, Q8R1S0
      UniProtKB/TrEMBL
      D3YW66
      Related
      ENSMUSP00000105905.2, ENSMUST00000110276.8
      Conserved Domains (1) summary
      cl21454
      Location:57471
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_006515700.2XP_006515763.1  ubiquinone biosynthesis monooxygenase COQ6, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:45388
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_381514.3 RNA Sequence

      Related
      ENSMUST00000152913.8