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    PFF1 Pff1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852366, updated on 9-Dec-2024

    Summary

    Official Symbol
    PFF1
    Official Full Name
    Pff1p
    Primary source
    SGD:S000000278
    Locus tag
    YBR074W
    See related
    AllianceGenome:SGD:S000000278; FungiDB:YBR074W; VEuPathDB:YBR074W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YBR075W
    Summary
    Predicted to enable metalloexopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Located in fungal-type vacuole membrane. Orthologous to human ERMP1 (endoplasmic reticulum metallopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See PFF1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (386286..389216)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DNA-dependent ATPase RDH54 Neighboring gene Ecm8p Neighboring gene Slm4p

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding  
    enables metalloexopeptidase activity  
    enables metallopeptidase activity  
    enables zinc ion binding PubMed 
    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in proteolysis  
    involved_in proteolysis  
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane PubMed 
    located_in fungal-type vacuole membrane PubMed 
    located_in membrane  
    located_in vacuolar membrane  
    located_in vacuole  

    General protein information

    Preferred Names
    Pff1p
    NP_009630.3
    • Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to M28 family of metalloproteases; has lumenal-facing protease domain; proposed role in vacuole physiology; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      386286..389216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178422.2 → NP_009630.3  TPA: Pff1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009630.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ74, P38244, P38245, Q86ZS2
      UniProtKB/TrEMBL
      G2W980, N1P8C2
      Conserved Domains (2) summary
      cd03875
      Location:50 → 354
      M28_Fxna_like; M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1
      cl02291
      Location:366 → 443
      DUF2189; Predicted integral membrane protein (DUF2189)
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