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    translation initiation factor 2A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852945, updated on 17-Dec-2024

    Summary

    Official Full Name
    translation initiation factor 2A
    Primary source
    SGD:S000003286
    Locus tag
    YGR054W
    See related
    AllianceGenome:SGD:S000003286; FungiDB:YGR054W; VEuPathDB:YGR054W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables translation initiation factor activity. Involved in translational initiation. Acts upstream of or within negative regulation of translation. Located in cytosolic ribosome. Part of cytosolic small ribosomal subunit. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (596693..598621)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene protein kinase FMP48 Neighboring gene Mco32p Neighboring gene Mup1p Neighboring gene RSC subunit protein RSC1

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding PubMed 
    enables mRNA binding  
    enables ribosome binding  
    enables tRNA binding  
    enables translation initiation factor activity  
    enables translation initiation factor activity PubMed 
    enables translation initiation factor activity  
    enables translation initiation factor activity PubMed 
    Component Evidence Code Pubs
    located_in cytosolic ribosome PubMed 
    part_of cytosolic small ribosomal subunit  
    part_of cytosolic small ribosomal subunit PubMed 

    General protein information

    Preferred Names
    translation initiation factor 2A
    NP_011568.3
    • Eukaryotic initiation factor eIF2A; associates specifically with both 40S subunits and 80S ribosomes, and interacts genetically with both eIF5b and eIF4E; physically interacts with Ssd1p, and associates with mRNAs encoding proteins required for cell wall organization, and some of which require the presence of Ssd1p; translational repressor of cell wall-related proteins; interacts physically and genetically with Xrn1p; homologous to mammalian eIF2A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      596693..598621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181183.4 → NP_011568.3  TPA: translation initiation factor 2A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011568.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUI9, P53235, Q45U32
      UniProtKB/TrEMBL
      A6ZV39, B3LIG9, C7GXN7, C8Z8U8, G2WEE1, N1P5R3
      Conserved Domains (2) summary
      COG5354
      Location:1 → 637
      COG5354; Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]
      sd00039
      Location:235 → 281
      7WD40; WD40 repeat [structural motif]
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