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    2mit 2mit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41616, updated on 9-Dec-2024

    Summary

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    Official Symbol
    2mitprovided by FlyBase
    Official Full Name
    2mitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260793
    Locus tag
    Dmel_CG42573
    See related
    AllianceGenome:FB:FBgn0260793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10148; CG17319; CG42573; CT28541; CT38314; Dmel\CG42573
    Old locus tag
    Dmel_CG10148; Dmel_CG17319
    Summary
    Involved in short-term memory. Is expressed in several structures, including Kenyon cell; adult gnathal ganglion; adult head; ellipsoid body; and presumptive embryonic/larval nervous system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See 2mit in Genome Data Viewer
    Location:
    87D13-87D14; 3-53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13121951..13155687, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8947673..8981409, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene timeout Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46019 Neighboring gene long non-coding RNA:CR45109 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arginine kinase interacts with 2MIT and is involved in Drosophila melanogaster short-term memory. Bozzato A, et al. J Insect Physiol, 2020 Nov-Dec. PMID 33011181
    2. Visualization of binding patterns for five Leucine-rich repeat proteins in the Drosophila embryo. Bali N, et al. MicroPubl Biol, 2019 Dec 18. PMID 32550403, Free PMC Article
    3. Drosophila timeless2 is required for chromosome stability and circadian photoreception. Benna C, et al. Curr Biol, 2010 Feb 23. PMID 20153199
    4. 2mit, an intronic gene of Drosophila melanogaster timeless2, is involved in behavioral plasticity. Baggio F, et al. PLoS One, 2013. PMID 24098788, Free PMC Article
    5. Evidence of abundant stop codon readthrough in Drosophila and other metazoa. Jungreis I, et al. Genome Res, 2011 Dec. PMID 21994247, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arginine kinase interacts with 2MIT and is involved in Drosophila melanogaster short-term memory.
      Title: Arginine kinase interacts with 2MIT and is involved in Drosophila melanogaster short-term memory.
    2. 2mit, an intronic gene of Drosophila melanogaster timeless2, is involved in behavioral plasticity.
      Title: 2mit, an intronic gene of Drosophila melanogaster timeless2, is involved in behavioral plasticity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c13148607-13143088 mobile_element_type = transposon:mdg3{}1351

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    2mit
    Names
    2mit-PA
    2mit-PB
    2mit-PC
    2mit-PD
    CG42573-PA
    CG42573-PB
    CG42573-PC
    CG42573-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13121951..13155687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142001.4 → NP_650258.2  2mit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650258.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFY9
      Conserved Domains (4) summary
      cd00116
      Location:124 → 355
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:172 → 194
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:379 → 415
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:193 → 253
      LRR_8; Leucine rich repeat

    2. NM_001275600.2 → NP_001262529.1  2mit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262529.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFU1
      Conserved Domains (4) summary
      cd00116
      Location:124 → 355
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:172 → 194
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:379 → 415
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:193 → 253
      LRR_8; Leucine rich repeat

    3. NM_001300382.1 → NP_001287311.1  2mit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287311.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFY9
      Conserved Domains (4) summary
      cd00116
      Location:124 → 355
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:172 → 194
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:379 → 415
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:193 → 253
      LRR_8; Leucine rich repeat

    4. NM_001300381.1 → NP_001287310.1  2mit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287310.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFY9
      Conserved Domains (4) summary
      cd00116
      Location:124 → 355
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:172 → 194
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:379 → 415
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:193 → 253
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFU1 A0A0B4KFU1
    Q9VFY9 Q9VFY9

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