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| Status |
Public on Aug 15, 2009 |
| Title |
Letrozole (Femara) early response to treatment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Tumorigenic breast cancer cells characterized by high CD44 and low or undetectable CD24 levels (CD44+/CD24-/low) may be resistant to conventional therapies and responsible for cancer relapse. We defined a “signature” expression pattern of hundreds of genes associated with CD44+/CD24-/low, mammosphere-forming cells. In a panel of patient breast tumors, this tumorigenic gene signature was found exclusively manifested in tumors of the recently identified “claudin-low” molecular profile subtype characterized by overexpression of many mesenchymal-associated genes, suggesting that these tumors have pre-existing higher levels of tumorigenic cells. Furthermore, when comparing the expression profiles of paired breast cancer core biopsies before versus after hormone therapy or chemotherapy, both the tumorigenic and “claudin-low” signatures were more active in about half of tumors after treatment, indicative of a greater enrichment of tumorigenic cells as a result of treatments targeting the bulk tumor cells.
Keywords: two group comparison
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| Overall design |
Biopsies were taken from the same subjects both pretreatment and after 10-14 days Letrozol, 2.5 mg/day, oral.
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| Contributor(s) |
Creighton C, Lewis M, Chang J |
| Citation(s) |
19666588 |
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| Submission date |
Jan 25, 2008 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Chad Creighton |
| E-mail(s) |
[email protected]
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| Organization name |
Baylor College of Medicine
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| Department |
Biostatistics, Ducan Cancer Center
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| Street address |
One Baylor Plaza, Mail Stop: BCM305
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| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (36)
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| GSM259581 |
patient40;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259582 |
patient50;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259583 |
patient109;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259584 |
patient112;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259585 |
patient114;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259586 |
patient116;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259587 |
patient117;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259588 |
patient126;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259589 |
patient133;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259590 |
patient136;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259591 |
patient137;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259592 |
patient152;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259593 |
patient159;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259594 |
patient161;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259595 |
patient173;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259596 |
patient190;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259597 |
patient193;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259598 |
patient195;female;breast tumor;Letrozole, 2.5mg/day,oral, 3 months |
| GSM259599 |
patient40;pretreatment;female;breast tumor |
| GSM259600 |
patient50;pretreatment;female;breast tumor |
| GSM259601 |
patient109;pretreatment;female;breast tumor |
| GSM259602 |
patient112;pretreatment;female;breast tumor |
| GSM259603 |
patient114;pretreatment;female;breast tumor |
| GSM259604 |
patient116;pretreatment;female;breast tumor |
| GSM259605 |
patient117;pretreatment;female;breast tumor |
| GSM259606 |
patient126;pretreatment;female;breast tumor |
| GSM259607 |
patient133;pretreatment;female;breast tumor |
| GSM259608 |
patient136;pretreatment;female;breast tumor |
| GSM259609 |
patient137;pretreatment;female;breast tumor |
| GSM259610 |
patient152;pretreatment;female;breast tumor |
| GSM259611 |
patient159;pretreatment;female;breast tumor |
| GSM259612 |
patient161;pretreatment;female;breast tumor |
| GSM259613 |
patient173;pretreatment;female;breast tumor |
| GSM259614 |
patient190;pretreatment;female;breast tumor |
| GSM259615 |
patient193;pretreatment;female;breast tumor |
| GSM259616 |
patient195;pretreatment;female;breast tumor |
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| Relations |
| BioProject |
PRJNA108483 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE10281_RAW.tar |
293.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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