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Series GSE104122 Query DataSets for GSE104122
Status Public on Sep 25, 2017
Title IMM_IL-17RC_KO mice_exp1
Organism Mus musculus
Experiment type Expression profiling by array
Summary This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of IL-17A signaling mice attenuated tissue repair of DSS-induced damage in colon epithelium and markedly reduced tumor development in AOM/DSS model of colitis-associated cancer. The goal of these studies is to identify genes associated with IL-17RC deficiency during AOM-DSS induced tumorigenesis
 
Overall design Wild-type and IL-17RC KO mice were subjected to AOM-DSS induced tumorigenic protocol. Treated/untreated mice were sacrificed and their colons resected for total RNA at different time points during the AOM-DSS treatment.
 
Contributor(s) Carman J, Yang W, Zhu J, Zepp J
Citation(s) 29070673
NIH grant(s)
Grant ID Grant title Affiliation Name
P01 CA062220 Integrated EGFR function in cytokine-driven inflammation and cancer CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE - CWRU GEORGE ROBERT STARK
Submission date Sep 22, 2017
Last update date Jul 25, 2021
Contact name Junjie Zhao
Organization name Cleveland Clinic Lerner Research Institute
Department Immunology
Lab Xiaoxia Li
Street address 9500 Euclid Avenue, NE4256
City Cleveland
State/province Ohio
ZIP/Postal code 44195
Country USA
 
Platforms (1)
GPL11180 [HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate
Samples (36)
GSM2790273 IL17RC_EPA02P1_KO mouse_colon_untreated_r1
GSM2790274 IL17RC_EPA04P1_WT mouse_colon_untreated_r2
GSM2790275 IL17RC_EPA05P1_WT mouse_colon_untreated_r4
Relations
BioProject PRJNA411836

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE104122_RAW.tar 80.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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