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| Status |
Public on Apr 10, 2018 |
| Title |
Bone density loci identified by genome-wide association studies segregate a lineage-specific PU.1-dependent gene regulatory network in osteoclasts [MoEx-1_0-st array] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Eavluation of temporal expression kinetics during mouse osteoclast differentiation evaluated by microarray.
We overlayed gene expression data with correspoding DNA binding data from MITF and PU.1 ChIP-seq to evaluate gene regulatory networks in osteoclasts.
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| |
|
| Overall design |
Either, mouse myeloid precurosrs or human osteoclast precurosrs were treated with osteoclast differentiation medim for 1.5 days and 3 days and gene expression compared to precurosrs treated with CSF-1 alone.
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| |
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| Contributor(s) |
Sharma SM, Ostrowski MC |
| Citation(s) |
29619268 |
| |
| Submission date |
Nov 23, 2017 |
| Last update date |
Apr 10, 2018 |
| Contact name |
Michael C Ostrowski |
| E-mail(s) |
[email protected]
|
| Organization name |
Medical University of South Carolina
|
| Department |
Biochemistry and Molecular Biology
|
| Lab |
Ostrowski
|
| Street address |
86 Jonathan Lucas street
|
| City |
Charleston |
| State/province |
SC |
| ZIP/Postal code |
29425 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6096 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version] |
|
| Samples (9)
|
| GSM2863966 |
Murine myeloid precursors treated with CSF-1 alone 1 |
| GSM2863967 |
Murine myeloid precursors treated with CSF-1 alone 2 |
| GSM2863968 |
Murine myeloid precursors treated with CSF-1 alone 3 |
| GSM2863969 |
Murine myeloid precursors treated with CSF-1and RANKL for 1.5 days 1 |
| GSM2863970 |
Murine myeloid precursors treated with CSF-1and RANKL for 1.5 days 2 |
| GSM2863971 |
Murine myeloid precursors treated with CSF-1and RANKL for 1.5 days 3 |
| GSM2863972 |
Murine myeloid precursors treated with CSF-1and RANKL for 3 days 1 |
| GSM2863973 |
Murine myeloid precursors treated with CSF-1and RANKL for 3 days 2 |
| GSM2863974 |
Murine myeloid precursors treated with CSF-1and RANKL for 3 days 3 |
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| This SubSeries is part of SuperSeries: |
| GSE107297 |
Bone density loci identified by genome-wide association studies segregate a lineage-specific PU.1-dependent gene regulatory network in osteoclasts |
|
| Relations |
| BioProject |
PRJNA419649 |
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