|
| Status |
Public on Mar 31, 2020 |
| Title |
Regulatory divergence during pig limb evolution |
| Organism |
Sus scrofa |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Genome-wide comparative analyses of the open chromatin profiles between equivalent stages of mouse and pig limb bud development reveal the extensive functional divergence of their limb regulomes. These alterations affect evolutionary conserved regions located in the genomic landscapes of genes with essential functions during limb development. This analysis uncovers the widespread regulatory changes that appear to underlie the morphological diversion of the artiodactyl limb from the pentadactyl blueprint of tetrapods.
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| |
|
| Overall design |
ATAC-seq analysis on dissected D21 and D24 pig forelimb buds
|
| |
|
| Contributor(s) |
Lopez-Rios J, Zeller R, Tissieres V, Geier F |
| Citation(s) |
32268095 |
| |
| Submission date |
Feb 08, 2019 |
| Last update date |
Nov 18, 2021 |
| Contact name |
DBM Bioinformatics Core Facility |
| Phone |
+41612073541
|
| Organization name |
University of Basel
|
| Department |
Departement of Biomedicine
|
| Street address |
Hebelstrasse 20
|
| City |
Basel |
| State/province |
BS |
| ZIP/Postal code |
4053 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL20983 |
Illumina NextSeq 500 (Sus scrofa) |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE126293 |
Regulatory divergence during limb evolution |
|
| Relations |
| BioProject |
PRJNA521488 |
| SRA |
SRP184669 |
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