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| Status |
Public on Oct 18, 2022 |
| Title |
Gene expression profiling of MYC inducible murine tumor models (tissues) [microarray] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The transcription factor, c-MYC, is a proto-oncogene that is activated in many types of cancer. To study how MYC promotes and maintains the neoplastic phenotype, we use tetracycline-regulated systems in transgenic mice whereby we can conditionally activate MYC. We profile the changes in gene expression when MYC is activated versus inactivated in order to identify a gene signature that is associated with the ability of MYC to promote tumorigenesis.
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| Overall design |
Total RNA was obtained from mouse tumors, driven by the activation of MYC (or another oncogene), as well as from the tissue of control FVB/N mice.
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| Contributor(s) |
Sullivan DK, Felsher DW |
| Citation(s) |
36207533 |
| |
| Submission date |
Jan 07, 2020 |
| Last update date |
Oct 18, 2022 |
| Contact name |
Dean Felsher |
| E-mail(s) |
[email protected]
|
| Organization name |
Stanford University
|
| Department |
Medicine
|
| Lab |
Felsher Lab
|
| Street address |
269 Campus Drive
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| City |
Stanford |
| State/province |
CA |
| ZIP/Postal code |
94305 |
| Country |
USA |
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| Platforms (2) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (38)
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| This SubSeries is part of SuperSeries: |
| GSE143254 |
Gene expression profiling of MYC inducible murine tumor models |
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| Relations |
| BioProject |
PRJNA599414 |
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