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| Status |
Public on Jul 23, 2024 |
| Title |
Microarray expression data of HCT116 with treatment (EI-52) or controls (DMSO) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The RAS pathway is frequently exploited by cancer cells to sustain their proliferation and survival. ERK is the most distal kinase in the RAS signaling cascade, playing a pivotal role in signaling output.
We performed a transcriptomic analysis to obtain an overview of the consequences of EI-52 (CER) treatment, an inhibitor of ERK protein-protein interaction, on the global cellular transcriptional activity.
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| Overall design |
Messenger RNA was extracted from HCT116, after 18h treatment in triplicate with 6µM of EI52 (CER) or DMSO.
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| Contributor(s) |
Virard F, Renno T, Coste I, Saintigny P |
| Citation(s) |
39147750 |
| |
| Submission date |
Jul 03, 2020 |
| Last update date |
Sep 12, 2024 |
| Contact name |
PIERRE SAINTIGNY |
| E-mail(s) |
[email protected]
|
| Organization name |
Centre Léon Bérard
|
| Street address |
28 Rue Laennec
|
| City |
Lyon |
| ZIP/Postal code |
69008 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL22321 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG_v20] |
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| Samples (6)
|
| GSM4653822 |
HCT116_CER1_4: EI-52 (CER) treated HCT116, replicate 1 |
| GSM4653823 |
HCT116_CER2_5: EI-52 (CER) treated HCT116, replicate 2 |
| GSM4653824 |
HCT116_CER3_6: EI-52 (CER) treated HCT116, replicate 3 |
| GSM4653825 |
HCT116_DMSO1_1: DMSO treated HCT116, replicate 1 |
| GSM4653826 |
HCT116_DMSO2_2: DMSO treated HCT116, replicate 2 |
| GSM4653827 |
HCT116_DMSO3_3: DMSO treated HCT116, replicate 3 |
|
| Relations |
| BioProject |
PRJNA643987 |
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