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| Status |
Public on Oct 01, 2009 |
| Title |
Expression data using esophageal epithelia from 3 month old-mice lacking the transcription factor Klf4 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Using the ED-L2 promoter of Epstein-Barr virus to drive Cre, we obtained tissue specific ablation of Klf4 in the squamous epithelia of the esophagus.
Using a functional genomic approach, we showed decreased expression of critical late-stage differentiation factors and identified alterations of several genes important in cellular differentiation.
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| Overall design |
For all experiments with ED-L2-Cre/Klf4loxp/loxp mice (mutant mice), sex-matched littermate Klf4loxp/loxp mice lacking the Cre transgene served as controls. 3 mutant mice and 3 controls were used.
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| |
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| Contributor(s) |
Katz JP, Tetreault MP |
| Citation(s) |
20347813 |
| |
| Submission date |
Jul 31, 2009 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Jonathan P. Katz |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Pennsylvania
|
| Department |
Medicine/Gastroenterology
|
| Street address |
913 BRBII/III, 421 Curie Blvd.
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA118873 |
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