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| Status |
Public on Apr 30, 2012 |
| Title |
Comparison of gene expression profiles in diploid and transformed tetraploid MEF cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We propose that abnormal DNA content in tetraploid cells can alter the gene expression profile, contributing to the cellular transformation. To test this hypothesis, we employ mRNA microarray to compare the gene expression profile in transformed tetraploid cells with that in the parent diploid cells.
Keywords: gene expression profile determination
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| Overall design |
Total RNA were extracted from diploid or tetraploid cells (n = 3 for each cell lines. mRNA microarray hybridization was conducted. Data were collected and analyzed.
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| Contributor(s) |
Wu X, Zheng L, Zhou M, Dai H, Shen B |
| Citation(s) |
22569363 |
| |
| Submission date |
Oct 29, 2009 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Xiwei Wu |
| E-mail(s) |
[email protected]
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| Organization name |
City of Hope National Medical Center
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| Department |
Computational and Quantitative Medicine
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| Street address |
1500 E. Duarte Rd.
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| City |
Duarte |
| State/province |
CA |
| ZIP/Postal code |
91010 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE18815 |
Comparison of diploid and transformed tetraploid MEF cells: gene expression and DNA methylation profiling |
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| Relations |
| BioProject |
PRJNA123855 |
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