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| Status |
Public on Apr 01, 2022 |
| Title |
IL-17RA blockade by brodalumab hidradenitis suppurativa |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The goal of this study is to characterize the molecular response of HS patients to brodalumab therapy in skin and serum, and to identify biomarkers of treatment response. Ten participants that received 210 mg/1.5mL brodalumab subcutaneously at week 0, 1, 2, 4 and every 2 weeks after were included in this molecular profiling study (NCT03960268). RNA-sequencing of nonlesional, perilesional and lesional HS skin biopsies was assessed.
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| Overall design |
Punch biopsies of nonlesional, perilesional and lesional HS skin were collected under ultrasound guidance as part of NCT03960268. Biopsies were collected prior to treatment (baseline) and at week 12, with an optional week 4 biopsy.
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| Contributor(s) |
Navrazhina K, Frew JW, Williams SC, Grand D, Gonzalez J, Garcet S, Krueger J |
| Citation(s) |
35191018 |
| |
| Submission date |
Nov 21, 2021 |
| Last update date |
Jul 01, 2022 |
| Contact name |
James Krueger |
| E-mail(s) |
[email protected]
|
| Phone |
212-327-7730
|
| Organization name |
The Rockefeller University
|
| Department |
Center for Clinical and Translational Science
|
| Lab |
Laboratory of Investigative Dermatology
|
| Street address |
1230 York Avenue
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (75)
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| Relations |
| BioProject |
PRJNA782312 |
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