 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Jan 20, 2010 |
| Title |
In vivo actin cross-linking induced by type VI secretion system is associated with intestinal inflammation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
To determine whether the Vibrio cholerae type VI secretion system (T6SS) is functional during animal infection, derivatives of V52 were used to infect infant mice. In this infection model, a diarrheal response occurred and effector translocation could be detected. These host responses were dependent on a functional T6SS and on the actin cross-linking effector domain of VgrG-1.
Gene expression and histological studies showed innate immune activation and immune cell infiltration in the intestinal lumen.
|
| |
|
| Overall design |
3 infection groups (mock, V52, ACD), 3 biological replicates per group.
|
| |
|
| Contributor(s) |
Ma A, Mekalanos J |
| Citation(s) |
20150509 |
| |
| Submission date |
Jan 19, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Amy Ma |
| Organization name |
Harvard Medical School
|
| Department |
Microbiology
|
| Street address |
200 Longwood Ave D1-411
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (9)
|
| GSM498429 |
intestine, mock-infected, biol rep1 |
| GSM498430 |
intestine, V52-infected, biol rep1 |
| GSM498431 |
intestine, ACD-infected, biol rep1 |
| GSM498432 |
intestine, mock-infected, biol rep2 |
| GSM498433 |
intestine, V52-infected, biol rep2 |
| GSM498434 |
intestine, ACD-infected, biol rep2 |
| GSM498435 |
intestine, mock-infected, biol rep3 |
| GSM498436 |
intestine, V52-infected, biol rep3 |
| GSM498437 |
intestine, ACD-infected, biol rep3 |
|
| Relations |
| BioProject |
PRJNA120179 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE19946_RAW.tar |
36.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...