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| Status |
Public on Oct 02, 2010 |
| Title |
Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
In order to explore the functions of carbonic anhydrase VI (CAVI) more fully, we examined the transcriptomic responses to CAVI deficiency in the submandibular gland, stomach, and duodenum of Car6-/- mice by cDNA microarray. 94, 56, and 127 genes were up- or down-regulated in the above-mentioned tissues of Car6-/- mice, respectively. The functional clustering of differentially expressed genes revealed a number of altered biological processes. In the duodenum, the significantly affected biological pathways included immune system process and retinol metabolic process. Response to oxidative stress and brown fat cell differentiation changed remarkably in the submandibular gland. Notably, the submandibular gland, stomach, and duodenum shared one prominent transcriptional susceptibility pathway-catabolic process.
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| Overall design |
Submandibular gland, stomach, and duodenum samples were collected from three wild-type and three Car6-/- female mice, respectively, at the age of two months. Total RNAs were purified and used for cDNA microarray.
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| Contributor(s) |
Pan P, Käyrä K, Leinonen J, Nissinen M, Parkkila S, Rajaniemi H |
| Citation(s) |
20835760 |
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| Submission date |
Feb 19, 2010 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Pei-wen Pan |
| Organization name |
Institute of Medical Technology, University of Tampere
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| Street address |
Biokatu 6
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| City |
Tampere |
| ZIP/Postal code |
33520 |
| Country |
Finland |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (18)
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| GSM512112 |
submandibular gland wild type rep1A |
| GSM512113 |
submandibular gland wild type rep2A |
| GSM512114 |
submandibular gland knockout rep1A |
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| Relations |
| BioProject |
PRJNA125589 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE20423_RAW.tar |
3.1 Mb |
(http)(custom) |
TAR |
| GSE20423_non-normalized.txt.gz |
3.0 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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