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| Status |
Public on Jun 04, 2023 |
| Title |
TRIM28 modulates progesterone and estrogne signaling in endometrium [mouseD3.5-RNAseq-mm10] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
TRIM28 interacts with PGR and ESR1 in both human and mouse uterus to modulate estrogen and progesterone signaling. Knocking down of TRIM28 in the human endometrial stromal cells imparied decidualization in vitro. Deletion of TRIM28 from mouse uterus disrupted uterine stromal decidualization leading to infertility. Addtionally, TRIM28 deletion caused abnormal accumulation of TRIM28 postive and PGR negative cells in the stroma.
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| Overall design |
Four TRIM28f/f (TRff) and TRIM28d/d (TRdd) mouse uterus were collected at pregnancy day 3.5 for RNA-Seq analysis
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| Contributor(s) |
Li R, Wang T, Wu S, Lydon JP, DeMayo FJ |
| Citation(s) |
37528140 |
| |
| Submission date |
Jun 03, 2022 |
| Last update date |
Aug 10, 2023 |
| Contact name |
Franco Demayo |
| E-mail(s) |
[email protected]
|
| Organization name |
NIEHS
|
| Street address |
111 TW Alexander Drive
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| City |
RTP |
| State/province |
NC |
| ZIP/Postal code |
27709 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE205481 |
TRIM28 modulates progesterone and estrogen signaling in endometrium |
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| Relations |
| BioProject |
PRJNA845802 |
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