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| Status |
Public on Oct 31, 2023 |
| Title |
microRNA expression data from liver samples of mice fed with a high fat diet for 24 weeks |
| Platform organism |
synthetic construct |
| Sample organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Although the global prevalence of obesity and type 2 diabetes is rising, the molecular mechanisms of dysregulated glucose and lipid metabolism are still incompletely understood. Epigenetic mechanisms were shown to have an impact in disease manifestation, but the underlying hepatic miRNA expression signature is not completely elucidated.
We used microarrays to perform a comprehensive screen of the complete microRNA transcriptome in liver samples of diet induced obese (DIO) mice in order to identify expressed microRNAs that might target genes of hepatic lipid and glucose metabolism.
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| Overall design |
Total RNA extracted from liver samples of DIO mice that were fed with a 58 % high fat diet (HFD) for 24 weeks were used for microarray measurement in order to establish a database for the murine microRNA expression pattern.
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| Web link |
https://www.biorxiv.org/content/10.1101/2023.10.02.560594v1
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| Contributor(s) |
Krause C, Britsemmer JH, Pfluger PT, Kirchner H, Schriever SC |
| Citation(s) |
39037913 |
| |
| Submission date |
Aug 16, 2022 |
| Last update date |
Jul 23, 2024 |
| Contact name |
Henriette Kirchner |
| E-mail(s) |
[email protected]
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| Organization name |
University of Lübeck
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| Department |
Institute for Human Genetics
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| Lab |
Epigenetics and Metabolism
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| Street address |
Ratzeburger Allee 160
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| City |
Lübeck |
| ZIP/Postal code |
23562 |
| Country |
Germany |
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| Platforms (1) |
| GPL21572 |
[miRNA-4] Affymetrix Multispecies miRNA-4 Array [ProbeSet ID version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA870047 |
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