|
| Status |
Public on May 13, 2011 |
| Title |
Controlled ErbB receptor dimerization |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In order to better understand signaling events following receptor dimerization involving HER2, we have generated an experimental system in which ErbB dimerization can be controlled.
We used gene expression microarrays to identify genes and pathways that are differentially activated by HER2 homodimers and HER2 containing heterodimers.
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| |
|
| Overall design |
MCF10A-HER2-FKBP-HA cells were treated with AP1510, TGFalpha or heregulin for 48 hrs prior to RNA harvest for array analysis.
|
| |
|
| Contributor(s) |
Ghosh R, Arteaga CL, Balko JM |
| Citation(s) |
21324925 |
| |
| Submission date |
Jun 10, 2010 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Ritwik Ghosh |
| Organization name |
Vanderbilt University
|
| Street address |
2220 Pierce Avenue, 777 PRB
|
| City |
Nashville |
| State/province |
TN |
| ZIP/Postal code |
37232 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA127399 |
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